cortisol acetonide

Base Information

• Chemical Name: cortisol acetonide
• CAS No.: 34332-34-8
• Molecular Formula: C₂₄H₃₄O₅
• Molecular Weight: 402.531
• Mol file: 34332-34-8.mol

Synonyms:

Chemical Property of cortisol acetonide

Chemical Property:

Purity/Quality:

CortisolAcetonide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Cortisol Acetonide is a glucocorticoid-specific steroid antagonist.

Technology Process of cortisol acetonide

There total 2 articles about cortisol acetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 11-hydroxy-17,21-isopropylidenedioxy-pregn-4-ene-3,20-dione (34332-34-8,103239-65-2)

Guidance literature:

Hydrocortison, 2,2-Dimethoxypropan, p-Toluolsulfonsaeure;

DOI:10.1021/jo00411a037

Reference yield:

→ 17α,21-(Dimethyl-methylendioxy)-Δ4-pregnenol-(11β)-dion-(3,20) (34332-34-8)

Guidance literature:

Reference yield:

17α,21-(Dimethyl-methylendioxy)-Δ4-pregnenol-(11β)-dion-(3,20) (34332-34-8) → 18,20-epoxy-11β,17α,20β,21-tetrahydroxypregn-4-ene-3-one (144302-17-0,81705-06-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / I₂, lead tetraacetate, calcium carbonate / benzene; cyclohexane / 2 h / Irradiation

2: 82 percent / Jones reagent / acetone; CH₂Cl₂ / 0.33 h / 5 °C

3: 80 percent / silver acetate / dioxane; H₂O / 4 h / Heating

4: DDQ / dioxane / 18 h / Ambient temperature

5: 89.5 percent / HCl / tetrahydrofuran / 1.5 h

With lead(IV) acetate; hydrogenchloride; jones reagent; iodine; silver(I) acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; calcium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; acetone; benzene;

DOI:10.1016/0039-128X(92)90095-Q

Downstream raw materials:

18,20-epoxy-11β,17α,20β,21-tetrahydroxypregn-4-ene-3-one