Technology Process of 2,13-diethyl-1,3,7,8,12,17,18,19-octamethyl-10,23-dihydrobilin dihydrobromide
There total 11 articles about 2,13-diethyl-1,3,7,8,12,17,18,19-octamethyl-10,23-dihydrobilin dihydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2, triethylamine / 10percent Pd/C / ethanol / 2 h
2: 100 - 102 °C / 20 - 22 Torr
3: phosphoryl chloride / diethyl ether / -78 °C
4: 1.) trifluoroacetic acid / 1.) 15 min, 2.) methanol, 1.5 h
5: 1.) HBr, acetic acid, trifluoroacetic acid / 1.) 6 h, 2.) methanol, 30 min
With
hydrogen bromide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; trichlorophosphate;
palladium on activated charcoal;
In
diethyl ether; ethanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2, triethylamine / 10percent Pd/C / ethanol / 2 h
2: 100 - 102 °C / 20 - 22 Torr
3: 1.76 g / phosphoryl chloride / diethyl ether / -78 °C
4: 1.) HBr, acetic acid, trifluoroacetic acid / 1.) 6 h, 2.) methanol, 30 min
With
hydrogen bromide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; trichlorophosphate;
palladium on activated charcoal;
In
diethyl ether; ethanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: phosphoryl chloride / diethyl ether / -78 °C
2: 1.) trifluoroacetic acid / 1.) 15 min, 2.) methanol, 1.5 h
3: 1.) HBr, acetic acid, trifluoroacetic acid / 1.) 6 h, 2.) methanol, 30 min
With
hydrogen bromide; acetic acid; trifluoroacetic acid; trichlorophosphate;
In
diethyl ether;
