1-Boc-4-(3-forMylphenyl)piperazine

Base Information

• Chemical Name: 1-Boc-4-(3-forMylphenyl)piperazine
• CAS No.: 1257849-25-4
• Molecular Formula: C₁₆H₂₂N₂O₃
• Molecular Weight: 290.362
• Mol file: 1257849-25-4.mol

Synonyms:

Chemical Property of 1-Boc-4-(3-forMylphenyl)piperazine

Chemical Property:

• Boiling Point: 436.1±40.0 °C(Predicted)
• PKA: 1.90±0.20(Predicted)
• Density: 1.154±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

1-Boc-4-(3-Formylphenyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Boc-4-(3-forMylphenyl)piperazine

There total 3 articles about 1-Boc-4-(3-forMylphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H26N2O4 → 4-(3-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (1257849-25-4)

Guidance literature:

With iron(III) chloride hexahydrate; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

3-(1,3-dioxolan-2-yl)-phenylbromide (17789-14-9) → 4-(3-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (1257849-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 100 °C / Inert atmosphere

2: iron(III) chloride hexahydrate / dichloromethane / 3 h / 20 °C

With iron(III) chloride hexahydrate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In dichloromethane; toluene;

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(3-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (1257849-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 100 °C / Inert atmosphere

2: iron(III) chloride hexahydrate / dichloromethane / 3 h / 20 °C

With iron(III) chloride hexahydrate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In dichloromethane; toluene;

upstream raw materials:

3-(1,3-dioxolan-2-yl)-phenylbromide

1-t-Butoxycarbonylpiperazine

Refernces

• 1、 -. "3-site piperazinylchalcone derivative, and pharmaceutical composition and applications thereof". . . Retrieved 2019/02/04.