acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester

Base Information

• Chemical Name: acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester
• CAS No.: 114872-67-2
• Molecular Formula: C₁₉H₂₄N₂O₅
• Molecular Weight: 360.41
• Mol file: 114872-67-2.mol

Synonyms:

Chemical Property of acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester

Chemical Property:

• Boiling Point: 561.4±50.0 °C(Predicted)
• Density: 1.217±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Diethyl2-acetamido-2-((5-methyl-1H-indol-3-yl)methyl)malonate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester

There total 3 articles about acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester (114872-67-2)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01104a028

Reference yield:

5-methyl-1H-indole (614-96-0) → acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester (114872-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: sodium ethylate; dimethyl sulfate; ethanol

With ethanol; sodium ethanolate; acetic acid; dimethyl sulfate;

DOI:10.1039/jr9480000705

Reference yield:

N,N-dimethyl-1-(5-methyl-1H-indol-3-yl)methanamine (30218-58-7) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → acetylamino-(5-methyl-indol-3-ylmethyl)-malonic acid diethyl ester (114872-67-2)

Guidance literature:

With ethanol; sodium ethanolate; dimethyl sulfate;

DOI:10.1039/jr9480000705

upstream raw materials:

N,N-dimethyl-1-(5-methyl-1H-indol-3-yl)methanamine

2-acetylaminomalonic acid diethyl ester

5-methyl-1H-indole

Downstream raw materials:

2-acetamido-3-(5-methyl-1H-indol-3-yl)propanoic acid