2-Methyl-2-(4-vinylphenyl)propanoic acid

Base Information

• Chemical Name: 2-Methyl-2-(4-vinylphenyl)propanoic acid
• CAS No.: 1256584-72-1
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.242
• Hs Code.: 2916399090
• Mol file: 1256584-72-1.mol

Synonyms:

Chemical Property of 2-Methyl-2-(4-vinylphenyl)propanoic acid

Chemical Property:

• Boiling Point: 306.8±11.0 °C(Predicted)
• PKA: 4.41±0.10(Predicted)
• Density: 1.076±0.06 g/cm3(Predicted)

Purity/Quality:

≥95% ^*data from raw suppliers

2-?Methyl-?2-?(4-?vinylphenyl)?propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-?Methyl-?2-?(4-?vinylphenyl)?propanoic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Technology Process of 2-Methyl-2-(4-vinylphenyl)propanoic acid

There total 4 articles about 2-Methyl-2-(4-vinylphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(1-hydroxy-ethyl)-phenyl]-2-methyl-propionic acid → 2-(4-Vinylphenyl)-2-methylpropanoic acid (1256584-72-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 6h; Reflux;

Reference yield:

methyl 2-methyl-2-phenylpropionate (57625-74-8) → 2-(4-Vinylphenyl)-2-methylpropanoic acid (1256584-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / carbon disulfide / 15 h / -10 - 45 °C

1.2: 0 - 20 °C

2.1: sodium tetrahydroborate; methanol / 0 °C

3.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; toluene-4-sulfonic acid; In carbon disulfide; toluene;

Reference yield:

2-(4-acetyl-phenyl)-2-methyl-propionic acid (857768-18-4) → 2-(4-Vinylphenyl)-2-methylpropanoic acid (1256584-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / 0 °C

2: toluene-4-sulfonic acid / toluene / 6 h / Reflux

With methanol; sodium tetrahydroborate; toluene-4-sulfonic acid; In toluene;

upstream raw materials:

methyl 2-methyl-2-phenylpropionate

2-(4-acetyl-phenyl)-2-methyl-propionic acid

Refernces