(3S*)-1,8-diamino-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12 trihydrochloride

Base Information

• Chemical Name: (3S*)-1,8-diamino-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12 trihydrochloride
• CAS No.: 1173019-26-5
• Molecular Formula: C₇H₁₉N₃*3ClH
• Molecular Weight: 266.536

Synonyms:

Chemical Property of (3S*)-1,8-diamino-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12 trihydrochloride

Chemical Property:

• Melting Point: 257-259°C (lit.)

Purity/Quality:

95% by CP; 98% atom D ^*data from raw suppliers

N-(3-Aminopropyl)butane-1,4-diamineTrihydrochloride(1,1,2,2,3,3,4,4-d8,98%)ChemicalPurity95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(3-Aminopropyl)butane-1,4-diamine Trihydrochloride (1,1,2,2,3,3,4,4-D8, 98%) Chemical Purity 95% (cas# 1173019-26-5) is the labelled version of Spermidine Trihydrochloride (S680408(P)), which was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines.

Technology Process of (3S*)-1,8-diamino-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12 trihydrochloride

There total 3 articles about (3S*)-1,8-diamino-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12 trihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3S*)-1,8-Bis[N,N'-(tert-butoxycarbonyl)amino]-4-(tert-butoxycarbonyl)-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12 → (3S*)-1,8-diamino-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12 trihydrochloride (1173019-26-5)

Guidance literature:

(3S*)-1,8-Bis[N,N'-(tert-butoxycarbonyl)amino]-4-(tert-butoxycarbonyl)-4-azaoctane-1,1,2,3,5,5,6,6,7,7,8,8-d12; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;

With hydrogenchloride; In water;

DOI:10.1002/chem.200801961

Reference yield: 78.0%

(+/-)-(1S,2S)-1,8-bis(N,N'-tert-butoxycarbonylamino)-4-(tert-butoxycarbonyl)-4-azaoctane-1,2,3,3,5,5,6,6,7,7,8,8-d12 → (+/-)-(1S,2S)-1,8-diamino-4-azaoctane-1,2,3,3,5,5,6,6,7,7,8,8-d12 trihydrochloride (1173019-26-5)

Guidance literature:

(+/-)-(1S,2S)-1,8-bis(N,N'-tert-butoxycarbonylamino)-4-(tert-butoxycarbonyl)-4-azaoctane-1,2,3,3,5,5,6,6,7,7,8,8-d12; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;

With hydrogenchloride; Further stages.;

DOI:10.1016/j.tet.2004.04.056

Reference yield:

(+/-)-(1S,2S)-1-(benzyl-tert-butoxycarbonylamino)-8-(tert-butoxycarbonylamino)-4-(tert-butoxycarbonyl)-4-azaoctane-1,2,3,3,5,5,6,6,7,7,8,8-d12 → (+/-)-(1S,2S)-1,8-diamino-4-azaoctane-1,2,3,3,5,5,6,6,7,7,8,8-d12 trihydrochloride (1173019-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 41 percent / H₂ / Pd(OH)2/C / methanol / 12 h / 20 °C / 760.05 Torr

2.1: CF₃CO₂H / CH₂Cl₂ / 0.25 h / 20 °C

2.2: 78 percent / aq. HCl

With hydrogen; trifluoroacetic acid; palladium dihydroxide; In methanol; dichloromethane;

DOI:10.1016/j.tet.2004.04.056

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