Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Base Information

Chemical Name:Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
CAS No.:104419-01-4
Molecular Formula:C₃₂H₅₄O₅S
Molecular Weight:550.844
Hs Code.:

Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Synonyms:

Suppliers and Price of Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

There total 16 articles about Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32249-55-1
(20S)-3α,5-cyclo-20-formyl-6β-methoxy-5α-pregnane

: 104419-01-4
Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) lithium diisopropylamide; 2.) potassium carbonate / 1.) THF, -78 deg C, 1 h; 2.) DMF, 100 deg C, 2 h, 50 deg C, 10 min

2: 76 percent / thionyl chloride, pyridine / 0.17 h / 0 °C

3: 69 percent / DBU / benzene / 0.25 h / Heating

4: 92 percent / hydrogen / 5 percent rhodium on alumina / ethyl acetate / 13 h / 5320 Torr

5: 99 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / Ambient temperature

6: triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

7: 81 percent / lithium aluminum hydride / diethyl ether / 0.5 h / Ambient temperature

8: pyridine / 4-(N,N-dimethylamino)pyridine / 6 h / Ambient temperature

9: p-toluenesulfonic acid / dioxane; H₂O / 1 h / 80 °C

10: 85 percent / pyridine / 4-(N,N-dimethylamino)pyridine / 8 h / Ambient temperature

11: 97 percent / 5 percent KOH / methanol / 1 h / Heating

12: 170 mg / p-toluenesulfonic acid / 2 h / Ambient temperature

13: 186 mg / pyridine / 1 h / Ambient temperature

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; dmap; Rh/Al₂O₃; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1021/ja00282a034

Reference yield:

: 104336-33-6
4-hydroxy-3-isopropyl-5H-furan-2-one

: 104419-01-4
Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) lithium diisopropylamide; 2.) potassium carbonate / 1.) THF, -78 deg C, 1 h; 2.) DMF, 100 deg C, 2 h, 50 deg C, 10 min

2: 76 percent / thionyl chloride, pyridine / 0.17 h / 0 °C

3: 69 percent / DBU / benzene / 0.25 h / Heating

4: 92 percent / hydrogen / 5 percent rhodium on alumina / ethyl acetate / 13 h / 5320 Torr

5: 99 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / Ambient temperature

6: triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

7: 81 percent / lithium aluminum hydride / diethyl ether / 0.5 h / Ambient temperature

8: pyridine / 4-(N,N-dimethylamino)pyridine / 6 h / Ambient temperature

9: p-toluenesulfonic acid / dioxane; H₂O / 1 h / 80 °C

10: 85 percent / pyridine / 4-(N,N-dimethylamino)pyridine / 8 h / Ambient temperature

11: 97 percent / 5 percent KOH / methanol / 1 h / Heating

12: 170 mg / p-toluenesulfonic acid / 2 h / Ambient temperature

13: 186 mg / pyridine / 1 h / Ambient temperature

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; dmap; Rh/Al₂O₃; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1021/ja00282a034

Reference yield:

: 104336-36-9
(20R,22R)-20-hydroxy-23-methoxymethoxy-6β-methoxy-3α,5-cyclo-5α-ergost-23-eno-28,22-lactone

: 104419-01-4
Methanesulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4S,5S)-5-((R)-1,2-dimethyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 76 percent / thionyl chloride, pyridine / 0.17 h / 0 °C

2: 69 percent / DBU / benzene / 0.25 h / Heating

3: 92 percent / hydrogen / 5 percent rhodium on alumina / ethyl acetate / 13 h / 5320 Torr

4: 99 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / Ambient temperature

5: triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

6: 81 percent / lithium aluminum hydride / diethyl ether / 0.5 h / Ambient temperature

7: pyridine / 4-(N,N-dimethylamino)pyridine / 6 h / Ambient temperature

8: p-toluenesulfonic acid / dioxane; H₂O / 1 h / 80 °C

9: 85 percent / pyridine / 4-(N,N-dimethylamino)pyridine / 8 h / Ambient temperature

10: 97 percent / 5 percent KOH / methanol / 1 h / Heating

11: 170 mg / p-toluenesulfonic acid / 2 h / Ambient temperature

12: 186 mg / pyridine / 1 h / Ambient temperature

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dmap; Rh/Al₂O₃; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1021/ja00282a034