fmoc-β-(1-azulenyl)-L-alanine

Base Information

Chemical Name:fmoc-β-(1-azulenyl)-L-alanine
CAS No.:273408-73-4
Molecular Formula:C₂₈H₂₃NO₄
Molecular Weight:437.495
Hs Code.:

Synonyms:

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Chemical Property of fmoc-β-(1-azulenyl)-L-alanine

Chemical Property:

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Technology Process of fmoc-β-(1-azulenyl)-L-alanine

There total 6 articles about fmoc-β-(1-azulenyl)-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93187-51-0
1-(dimethylaminomethyl)azulene

: 273408-73-4
fmoc-β-(1-azulenyl)-L-alanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 4 °C

2.1: sodium / ethanol / 0.25 h

2.2: 1 h / 85 °C

3.1: potassium hydroxide; water / ethanol / 70 °C

4.1: hydrogenchloride / tetrahydrofuran / 85 - 90 °C / Inert atmosphere

5.1: potassium hydroxide; acylase I from Aspergillus melleus / aq. phosphate buffer / 5 h / 37 °C / pH 2.5 / Enzymatic reaction

6.1: sodium carbonate / water; 1,4-dioxane / 3 h / Cooling with ice

With hydrogenchloride; acylase I from Aspergillus melleus; water; sodium; sodium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; aq. phosphate buffer; ethanol; water;
DOI:10.1039/c2cc37550h

Reference yield:

: 275-51-4
azulene

: 273408-73-4
fmoc-β-(1-azulenyl)-L-alanine

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / dichloromethane

1.2: 2 h / 0 - 20 °C

2.1: ethanol / 4 °C

3.1: sodium / ethanol / 0.25 h

3.2: 1 h / 85 °C

4.1: potassium hydroxide; water / ethanol / 70 °C

5.1: hydrogenchloride / tetrahydrofuran / 85 - 90 °C / Inert atmosphere

6.1: potassium hydroxide; acylase I from Aspergillus melleus / aq. phosphate buffer / 5 h / 37 °C / pH 2.5 / Enzymatic reaction

7.1: sodium carbonate / water; 1,4-dioxane / 3 h / Cooling with ice

With hydrogenchloride; acylase I from Aspergillus melleus; water; sodium; sodium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; aq. phosphate buffer; ethanol; dichloromethane; water;
DOI:10.1039/c2cc37550h

Reference yield:

: 40450-20-2
(azulene-1-ylmethyl)trimethylammonium iodide

: 273408-73-4
fmoc-β-(1-azulenyl)-L-alanine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / ethanol / 0.25 h

1.2: 1 h / 85 °C

2.1: potassium hydroxide; water / ethanol / 70 °C

3.1: hydrogenchloride / tetrahydrofuran / 85 - 90 °C / Inert atmosphere

4.1: potassium hydroxide; acylase I from Aspergillus melleus / aq. phosphate buffer / 5 h / 37 °C / pH 2.5 / Enzymatic reaction

5.1: sodium carbonate / water; 1,4-dioxane / 3 h / Cooling with ice

With hydrogenchloride; acylase I from Aspergillus melleus; water; sodium; sodium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; aq. phosphate buffer; ethanol; water;
DOI:10.1039/c2cc37550h