Technology Process of 4-(2-methylcyclopent-4-ene-1,3-dione-yl)butanoic acid, N-succinimidyl ester
There total 6 articles about 4-(2-methylcyclopent-4-ene-1,3-dione-yl)butanoic acid, N-succinimidyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) ozone, 2) dimethyl sulphide / 1) dichloromethane, -78 deg C, 2) to room temperature
2: 62 percent / CH2Cl2 / 20 h / Ambient temperature
3: H2 / 10percent palladium on charcoal / ethyl acetate
4: 1) phenyl selenenyl chloride, 2) 30percent aq. hydrogen peroxide / 1) ethyl acetate, room temperature, 4 h, 2) 3 h
5: 92 percent / trifluoroethanoic acid / 20 h / Ambient temperature
6: 1) iso-butylchloroformate, triethylamine, 2) triethylamine / 1) THF, room temperature, 1 h, 2) room temperature, 4 h
With
Phenylselenyl chloride; dimethylsulfide; hydrogen; dihydrogen peroxide; ozone; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)87134-9
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 62 percent / CH2Cl2 / 20 h / Ambient temperature
2: H2 / 10percent palladium on charcoal / ethyl acetate
3: 1) phenyl selenenyl chloride, 2) 30percent aq. hydrogen peroxide / 1) ethyl acetate, room temperature, 4 h, 2) 3 h
4: 92 percent / trifluoroethanoic acid / 20 h / Ambient temperature
5: 1) iso-butylchloroformate, triethylamine, 2) triethylamine / 1) THF, room temperature, 1 h, 2) room temperature, 4 h
With
Phenylselenyl chloride; hydrogen; dihydrogen peroxide; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)87134-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / 10percent palladium on charcoal / ethyl acetate
2: 1) phenyl selenenyl chloride, 2) 30percent aq. hydrogen peroxide / 1) ethyl acetate, room temperature, 4 h, 2) 3 h
3: 92 percent / trifluoroethanoic acid / 20 h / Ambient temperature
4: 1) iso-butylchloroformate, triethylamine, 2) triethylamine / 1) THF, room temperature, 1 h, 2) room temperature, 4 h
With
Phenylselenyl chloride; hydrogen; dihydrogen peroxide; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1016/S0040-4020(01)87134-9
