1,2-dichloro-3-iodo-5-methylbenzene

Base Information

• Chemical Name: 1,2-dichloro-3-iodo-5-methylbenzene
• CAS No.: 1192343-89-7
• Molecular Formula: C₇H₅Cl₂I
• Molecular Weight: 286.927
• Mol file: 1192343-89-7.mol

Synonyms:

Chemical Property of 1,2-dichloro-3-iodo-5-methylbenzene

Chemical Property:

• Boiling Point: 289.5±35.0 °C(Predicted)
• Density: 1.891±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dichloro-5-iodotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-dichloro-3-iodo-5-methylbenzene

There total 3 articles about 1,2-dichloro-3-iodo-5-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dichloro-5-methylphenylamine (13711-29-0) → 1,2-dichloro-3-iodo-5-methylbenzene (1192343-89-7)

Guidance literature:

2,3-dichloro-5-methylphenylamine; With hydrogenchloride; sodium nitrite; at 0 ℃; for 0.25h;

With potassium iodide; In water;

DOI:10.1002/anie.200504296

Reference yield:

2-chloro-4-methyl-6-nitroaniline (5465-33-8) → 1,2-dichloro-3-iodo-5-methylbenzene (1192343-89-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tert.-butylnitrite; copper dichloride / acetonitrile / 1.5 h / 65 °C

2: hydrogenchloride; iron / ethanol; water / 1.5 h / Reflux

3: sulfuric acid; sodium nitrite / acetic acid / 25 - 75 °C

With hydrogenchloride; tert.-butylnitrite; sulfuric acid; iron; copper dichloride; sodium nitrite; In ethanol; water; acetic acid; acetonitrile; 1: Sandmeyer reaction;

DOI:10.1016/j.bmc.2009.07.021

Reference yield:

2-chloro-4-methyl-benzenamine (615-65-6) → 1,2-dichloro-3-iodo-5-methylbenzene (1192343-89-7)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid; acetic anhydride / 1.17 h / 5 - 15 °C

2: tert.-butylnitrite; copper dichloride / acetonitrile / 1.5 h / 65 °C

3: hydrogenchloride; iron / ethanol; water / 1.5 h / Reflux

4: sulfuric acid; sodium nitrite / acetic acid / 25 - 75 °C

With hydrogenchloride; tert.-butylnitrite; sulfuric acid; nitric acid; acetic anhydride; iron; copper dichloride; sodium nitrite; In ethanol; water; acetic acid; acetonitrile; 2: Sandmeyer reaction;

DOI:10.1016/j.bmc.2009.07.021

upstream raw materials:

2,3-dichloro-5-methylphenylamine

2-chloro-4-methyl-6-nitroaniline

2-chloro-4-methyl-benzenamine