2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester
CAS No.:168470-76-6
Molecular Formula:C₃₀H₄₁N₅O₄S
Molecular Weight:567.753
Hs Code.:

2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

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Chemical Property of 2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

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Technology Process of 2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

There total 7 articles about 2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141595-75-7
(S)-2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

: 168470-76-6
2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 10percent Pd/C / methanol / 2 h / Ambient temperature

2: 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, N-methylmorpholine / tetrahydrofuran; dimethylformamide / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950591h

Reference yield:

: 20207-16-3
ethyl 2-amino-3-oxobutanoate hydrochloride

: 168470-76-6
2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

2: 46 percent / Lawesson's reagent / tetrahydrofuran / 5 h / Heating

3: 30percent HBr, AcOH / 3 h / Ambient temperature

4: 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, N-methylmorpholine / tetrahydrofuran; dimethylformamide / 18 h / Ambient temperature

With Lawessons reagent; 4-methyl-morpholine; hydrogen bromide; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm950591h

Reference yield:

: 133641-28-8
C₂₄H₂₆N₂O₆

: 168470-76-6
2-[(R)-1-{(S)-2-[(Azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

2: 46 percent / Lawesson's reagent / tetrahydrofuran / 5 h / Heating

3: 30percent HBr, AcOH / 3 h / Ambient temperature

4: 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, N-methylmorpholine / tetrahydrofuran; dimethylformamide / 18 h / Ambient temperature

With Lawessons reagent; 4-methyl-morpholine; hydrogen bromide; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm950591h