Technology Process of 2-(tert-butoxycarbonyl)-2-azaspiro[4.4]nonane-7-carboxylic acid
There total 9 articles about 2-(tert-butoxycarbonyl)-2-azaspiro[4.4]nonane-7-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; water; sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium periodate; ruthenium trichloride / water; acetonitrile; ethyl acetate / 20 °C
2.1: sulfuric acid / 70 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
3.2: 0.5 h / -60 °C / Inert atmosphere
4.1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0.5 h / 0 °C
5.1: methanol / 0.5 h / 20 °C
5.2: 20 °C
6.1: Lawessons reagent / toluene / 2 h / 100 °C
7.1: Raney nickel / tetrahydrofuran / 2 h / 65 °C
8.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C
9.1: methanol; sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C
With
Lawessons reagent; methanol; ruthenium trichloride; sodium periodate; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; water; ethyl acetate; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid / 70 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
2.2: 0.5 h / -60 °C / Inert atmosphere
3.1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0.5 h / 0 °C
4.1: methanol / 0.5 h / 20 °C
4.2: 20 °C
5.1: Lawessons reagent / toluene / 2 h / 100 °C
6.1: Raney nickel / tetrahydrofuran / 2 h / 65 °C
7.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C
8.1: methanol; sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C
With
Lawessons reagent; methanol; ruthenium trichloride; sodium periodate; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; water; toluene; acetonitrile;
