Technology Process of 3-(((tert-butoxycarbonyl)amino)methyl)cyclobutanecarboxylic acid
There total 7 articles about 3-(((tert-butoxycarbonyl)amino)methyl)cyclobutanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cis-3-(aminomethyl)cyclobutanecarboxylic acid hydrochloride;
With
sodium hydroxide;
In
1,4-dioxane; water;
for 0.166667h;
di-tert-butyl dicarbonate;
In
1,4-dioxane; water;
for 3h;
Inert atmosphere;
DOI:10.1007/s00726-012-1362-3
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 16 h / -10 - 20 °C / Inert atmosphere
1.2: 24 h / Inert atmosphere; Reflux
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere
3.1: ammonia; lithium / tetrahydrofuran; tert-butyl alcohol / -78 °C / Inert atmosphere
4.1: hydrogenchloride / water / Inert atmosphere
5.1: sodium hydroxide / water; 1,4-dioxane / 0.17 h
5.2: 3 h / Inert atmosphere
With
hydrogenchloride; ammonia; lithium; methanesulfonyl chloride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1007/s00726-012-1362-3
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen; palladium on activated charcoal; sodium carbonate / ethanol / 12 h / 20 °C
2.1: lithium borohydride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 16 h / -10 - 20 °C / Inert atmosphere
3.2: 24 h / Inert atmosphere; Reflux
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere
5.1: ammonia; lithium / tetrahydrofuran; tert-butyl alcohol / -78 °C / Inert atmosphere
6.1: hydrogenchloride / water / Inert atmosphere
7.1: sodium hydroxide / water; 1,4-dioxane / 0.17 h
7.2: 3 h / Inert atmosphere
With
hydrogenchloride; lithium borohydride; palladium on activated charcoal; ammonia; hydrogen; lithium; sodium carbonate; methanesulfonyl chloride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1007/s00726-012-1362-3
