Technology Process of (+)-2-(4-ethylphenyl)pyrrolidine
There total 2 articles about (+)-2-(4-ethylphenyl)pyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl (4-(4-ethylphenyl)-4-oxobutyl)carbamate;
With
trifluoroacetic acid;
In
dichloromethane;
for 3h;
Inert atmosphere;
Schlenk technique;
With
1,4-diaza-bicyclo[2.2.2]octane; titanium(IV) isopropylate; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis[4-(trifluoromethyl)phenyl]phosphino]ferrocene; hydrogen; potassium iodide;
In
tetrahydrofuran; toluene;
at 50 ℃;
for 13h;
under 38002.6 Torr;
Overall yield = 97 percent; Overall yield = 33.9 mg; enantioselective reaction;
Autoclave;
DOI:10.1055/s-0037-1611533
- Guidance literature:
-
tert-butyl (4-(4-ethylphenyl)-4-oxobutyl)carbamate;
With
trifluoroacetic acid;
In
dichloromethane;
for 3h;
Inert atmosphere;
Schlenk technique;
With
1,4-diaza-bicyclo[2.2.2]octane; titanium(IV) isopropylate; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis[4-(trifluoromethyl)phenyl]phosphino]ferrocene; hydrogen; potassium iodide;
In
tetrahydrofuran; toluene;
at 50 ℃;
for 13h;
under 38002.6 Torr;
Overall yield = 97 percent; Overall yield = 33.9 mg; enantioselective reaction;
Autoclave;
DOI:10.1055/s-0037-1611533
