Technology Process of chloro-6-(hydroxymethyl)pyrazine-2-carbonitrile
There total 4 articles about chloro-6-(hydroxymethyl)pyrazine-2-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-chloro-6-formylpyrazine-2-carbonitrile;
With
borane;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 1.5h;
With
hydrogenchloride; water;
In
tetrahydrofuran; diethyl ether;
With
sodium hydrogencarbonate;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper dichloride / acetonitrile / 0.17 h / 60 °C
1.2: 16 h / 60 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / toluene / 16 h / 100 °C / Inert atmosphere
3.1: osmium(VIII) oxide; sodium periodate; water / 1,4-dioxane / 16 h / 20 °C
4.1: borane / diethyl ether; tetrahydrofuran / 1.5 h / -78 °C
With
sodium periodate; osmium(VIII) oxide; borane; water; copper dichloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0) / toluene / 16 h / 100 °C / Inert atmosphere
2: osmium(VIII) oxide; sodium periodate; water / 1,4-dioxane / 16 h / 20 °C
3: borane / diethyl ether; tetrahydrofuran / 1.5 h / -78 °C
With
sodium periodate; osmium(VIII) oxide; borane; water;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; toluene;
