(S)-benzyl 3-aMinobutylcarbaMate

Base Information

• Chemical Name: (S)-benzyl 3-aMinobutylcarbaMate
• CAS No.: 1187927-77-0
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.287
• Mol file: 1187927-77-0.mol

Synonyms:

Chemical Property of (S)-benzyl 3-aMinobutylcarbaMate

Chemical Property:

• Boiling Point: 373.8±35.0 °C(Predicted)
• PKA: 12.56±0.46(Predicted)
• Density: 1.086±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-Cbz-amino-butyl-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl 3-aMinobutylcarbaMate

There total 8 articles about (S)-benzyl 3-aMinobutylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(3R)-N1-(benzyloxycarbonyl)-N3-(tert-butyloxycarbonyl)-1,3-diaminobutane → (R)-N1-(benzyloxycarbonyl)-1,3-diaminobutane (1187927-77-0)

Guidance literature:

With hydrogenchloride; at 0 - 20 ℃; for 3h;

DOI:10.1134/S1068162020060126

Reference yield: 75.0%

(3S)-N1-(benzyloxycarbonyl)-N3-(tert-butyloxycarbonyl)-1,3-diaminobutane (949916-62-5) → (S)-N1-(benzyloxycarbonyl)-1,3-diaminobutane (949916-64-7,1187927-77-0)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 3h; enantioselective reaction;

DOI:10.1134/S1068162015050064

Reference yield: 65.0%

N-(benzyloxycarbonyl)-1-amino-3-azidobutane → N1-(benzyloxycarbonyl)-1,3-diaminobutane (1187927-77-0)

Guidance literature:

N-(benzyloxycarbonyl)-1-amino-3-azidobutane; With triphenylphosphine; In tetrahydrofuran; for 1.5h; Reflux;

With methylamine; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.9b01666

upstream raw materials:

(3S)-N¹-(benzyloxycarbonyl)-N³-(tert-butyloxycarbonyl)-1,3-diaminobutane

benzyl chloroformate

N-(benzyloxycarbonyl)-4-aminobutanol-2

Refernces

• 1、 Chizhov, A. O.,Hyv?nen, M. T.,Kein?nen, T. A.,Khomutov, A. R.,Khomutov, M. A.,Kochetkov, S. N.,Ryzhov, I. M.,Salikhov, A. I.,Veps?l?inen, J.. "Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine". . p. 1061 - 1066. Retrieved 2020/12/30.
• 2、 -. "SUBSTITUTED FUSED[1,2]IMIDAZO[4,5-C] RING COMPOUNDS AND METHODS". Page/Page column 113. . Retrieved 2008/06/13.