Arginase inhibitor 1

Base Information

• Chemical Name: Arginase inhibitor 1
• CAS No.: 1345808-25-4
• Molecular Formula: C₁₃H₂₇BN₂O₄
• Molecular Weight: 286.179
• Mol file: 1345808-25-4.mol

Synonyms:

Chemical Property of Arginase inhibitor 1

Chemical Property:

• Boiling Point: 523.0±60.0 °C(Predicted)
• PKA: 2.22±0.44(Predicted)
• Density: 1.147±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

>98% ^*data from raw suppliers

Arginaseinhibitor1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes). It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 μM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.

Technology Process of Arginase inhibitor 1

There total 2 articles about Arginase inhibitor 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid dihydrochloride → (R)-2-amino-6-borono-2-[2-piperidin-1-yl-ethyl]-hexanoic acid (1345808-25-4)

Guidance literature:

With Dowex-50WX₈-400 ion resin; In water; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm400014c

Reference yield:

(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(2-(piperidin-1-yl)ethyl)-6-(3,3,4,4-tetramethylborolan-1-yl)-hexanoate → (R)-2-amino-6-borono-2-[2-piperidin-1-yl-ethyl]-hexanoic acid (1345808-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / Heating; Inert atmosphere

2: Dowex-50WX8?400 ion resin / water / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; In water;

DOI:10.1021/jm400014c

Refernces