[2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium

Base Information

Chemical Name:[2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium
CAS No.:1338579-83-1
Molecular Formula:C₂₁H₃₁O₈S*Na
Molecular Weight:471.488
Hs Code.:

Synonyms:

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Chemical Property of [2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium

Chemical Property:

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Technology Process of [2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium

There total 9 articles about [2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₉⁽²⁾H₅O₉S

: 1338579-83-1
[2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 1h;
DOI:10.1016/j.steroids.2011.05.014

Reference yield:

: 102900-58-3
17,20:20,21-bismethylenedioxy-11β-hydroxy-5β-pregnan-3-one

: 1338579-83-1
[2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium

Guidance literature:: Multi-step reaction with 7 steps

1: [D]-sodium hydroxide / 1,4-dioxane; CH₃OD; water-d2 / 22 h / 60 °C / Inert atmosphere

2: sodium borodeuteride / 1,4-dioxane; CH₃OD; D₂D / 0.5 h / 20 °C / Inert atmosphere

3: pyridine / 10 h / 20 °C

4: sodium acetate; pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C

5: hydrogen fluoride / tetrahydrofuran; ethanol / 8 h / 20 °C

6: sulfur trioxide trimethylamine complex / pyridine / 3 h / 20 °C

7: sodium hydroxide / methanol / 1 h / 20 °C

With pyridine; [D]-sodium hydroxide; sodium borodeuteride; hydrogen fluoride; sodium acetate; sulfur trioxide trimethylamine complex; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; CH₃OD; D₂D; water-d2;
DOI:10.1016/j.steroids.2011.05.014

Reference yield:

: 1338579-71-7
[2,2,3β,4,4-d5]-17,20:20,21-bismethylenedioxy-3α,11β-dihydroxy-5β-pregnan

: 1338579-83-1
[2,2,3β,4,4-d5]-3α,17α-dihydroxy-21-sulfooxy-5β-pregnane-11,20-dione sodium

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 10 h / 20 °C

2: sodium acetate; pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C

3: hydrogen fluoride / tetrahydrofuran; ethanol / 8 h / 20 °C

4: sulfur trioxide trimethylamine complex / pyridine / 3 h / 20 °C

5: sodium hydroxide / methanol / 1 h / 20 °C

With pyridine; hydrogen fluoride; sodium acetate; sulfur trioxide trimethylamine complex; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane;
DOI:10.1016/j.steroids.2011.05.014