N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Base Information

Chemical Name:N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
CAS No.:1388651-30-6
Molecular Formula:C₁₉H₁₈F₃N₅O₂S
Molecular Weight:437.445
Hs Code.:

N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Synonyms:

Suppliers and Price of N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Elenbecestat 99.77%
100mg
$ 2250.00

ChemScene
Elenbecestat 99.77%
50mg
$ 1640.00

ChemScene
Elenbecestat 99.77%
25mg
$ 965.00

ChemScene
Elenbecestat 99.77%
10mg
$ 500.00

ChemScene
Elenbecestat 99.77%
5mg
$ 295.00

Total 10 raw suppliers

Chemical Property of N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Elenbecestat 99.77% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

There total 27 articles about N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

: 1174321-06-2
5-(difluoromethyl)pyrazine-2-carboxylic acid

: (4aS,5R,7aS)-7a-(5-amino-2-fluorophenyl)-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

: 1388651-30-6
N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Guidance literature:: With thionyl chloride; at 0 - 10 ℃; Large scale;
DOI:10.1021/acs.oprd.1c00223

Reference yield: 78.0%

: C₂₄H₂₆F₃N₅O₄S

: 1388651-30-6
N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Guidance literature:: With formic acid; In toluene; at 20 - 25 ℃;
DOI:10.1021/acs.oprd.1c00223

Reference yield:

: N-((3S,4R,5R)-3-(2-fluorophenyl)-4-(hydroxymethyl)-5-methyltetrahydrofuran-3-ylcarbamothioyl)benzamide

: 1388651-30-6
N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 h / -20 - 22 °C

2: potassium carbonate / methanol / 6 h / 60 - 65 °C

3: trifluoroacetic acid; sulfuric acid; nitric acid / 0.5 h / 0 - 20 °C

4: ammonium chloride; iron; hydrogenchloride / water; ethanol / 2 h / 18 - 70 °C

5: thionyl chloride / toluene / 0 - 10 °C

With pyridine; hydrogenchloride; thionyl chloride; trifluoromethylsulfonic anhydride; sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; toluene;