ethylethyl (3-nitrobenzyl)phosphinate

Base Information

• Chemical Name: ethylethyl (3-nitrobenzyl)phosphinate
• CAS No.: 1606169-55-4
• Molecular Formula: C₁₁H₁₆NO₄P
• Molecular Weight: 257.226
• Mol file: 1606169-55-4.mol

Synonyms:

Chemical Property of ethylethyl (3-nitrobenzyl)phosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethylethyl (3-nitrobenzyl)phosphinate

There total 1 articles about ethylethyl (3-nitrobenzyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl ethylphosphonite (2651-85-6) + 1-bromomethyl-3-nitrobenzene (3958-57-4) → ethylethyl (3-nitrobenzyl)phosphinate (1606169-55-4)

Guidance literature:

at 140 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm401742r

Reference yield:

ethylethyl (3-nitrobenzyl)phosphinate (1606169-55-4) → ethyl ethyl(3-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}benzyl)phosphinate (1606168-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(ll) chloride / ethanol / 4 h / Reflux

2.1: hydrogenchloride / ethanol; water; 1,4-dioxane

2.2: Reflux

With hydrogenchloride; tin(ll) chloride; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jm401742r

Reference yield:

ethylethyl (3-nitrobenzyl)phosphinate (1606169-55-4) → ethyl ethyl(3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}benzyl)phosphinate (1606168-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(ll) chloride / ethanol / 4 h / Reflux

2.1: hydrogenchloride / ethanol; water; 1,4-dioxane

2.2: Reflux

With hydrogenchloride; tin(ll) chloride; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jm401742r

upstream raw materials:

diethyl ethylphosphonite

1-bromomethyl-3-nitrobenzene

Downstream raw materials:

ethyl [3-({6-[2-(benzyloxy)phenyl]pyrimidin-4-yl}amino)benzyl]ethylphosphinate

[3-({6-[2-(benzyloxy)phenyl]pyrimidin-4-yl}amino)benzyl]ethylphosphinic acid

ethyl (3-aminobenzyl)ethylphosphinate

ethyl ethyl(3-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}benzyl)phosphinate