(1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid

Base Information

Chemical Name:(1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid
CAS No.:1268882-43-4
Molecular Formula:C₈H₈N₂O₂
Molecular Weight:164.164
Hs Code.:

Synonyms:

Suppliers and Price of (1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
MK 1903
10mg
$ 480.00

TRC
MK1903
1mg
$ 115.00

Tocris
MK1903 ≥98%(HPLC)
10
$ 229.00

CSNpharm
MK1903
10mg
$ 172.00

CSNpharm
MK1903
5mg
$ 108.00

CSNpharm
MK1903
100mg
$ 1125.00

CSNpharm
MK1903
50mg
$ 703.00

CSNpharm
MK1903
25mg
$ 370.00

ApexBio Technology
MK1903
50mg
$ 1385.00

ApexBio Technology
MK1903
10mg
$ 339.00

Total 2 raw suppliers

Chemical Property of (1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid

Chemical Property:

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

MK 1903 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses MK 1903 is a potent GPR109A agonist that lowers free fatty acids in humans and may be used in the treatment of obesity and related weight disorders.

Technology Process of (1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid

There total 2 articles about (1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 895539-46-5,1268882-46-7
MK-1903

: 1268882-43-4
(1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid

Guidance literature:: MK-1903; With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 2h; Microwave irradiation;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 58001-78-8
bicyclo<3.1.0>hexan-2-one

: 1268882-43-4
(1aR,5aR)-1a,3,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

1.2: 15 h / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 60 °C / Microwave irradiation

With potassium tert-butylate; water; lithium hydroxide; In tetrahydrofuran;