TERT-BUTYL [(RS)-PYRROLIDIN-3-YL]CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL [(RS)-PYRROLIDIN-3-YL]CARBAMATE
• CAS No.: 140629-77-2
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.254
• Mol file: 140629-77-2.mol

Synonyms:

Chemical Property of TERT-BUTYL [(RS)-PYRROLIDIN-3-YL]CARBAMATE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TERT-BUTYL [(RS)-PYRROLIDIN-3-YL]CARBAMATE

There total 25 articles about TERT-BUTYL [(RS)-PYRROLIDIN-3-YL]CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-1-benzyl-3-(tert-butoxycarbonylamino)pyrrolidine (131852-53-4) → 3(S)-(tert-butoxycarbonylamino)pyrrolidine (122536-76-9,140629-77-2)

Guidance literature:

With 10% palladium on carbon; hydrogen; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2010.04.038

Reference yield: 100.0%

(3R)-1-benzyl-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine (131878-23-4) → 3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine (122536-77-0,140629-77-2)

Guidance literature:

With hydrogen; palladium dihydroxide; In tetrahydrofuran; ethanol; for 24h;

DOI:10.1021/jm010329a

Reference yield: 95.0%

(S)-3-<<(1,1-dimethylethoxy)carbonyl>amino>-1-pyrrolidinecarboxylic acid phenylmethyl ester (122536-74-7) → 3(S)-(tert-butoxycarbonylamino)pyrrolidine (122536-76-9,140629-77-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 21 - 25 ℃; for 0.5h; under 1639.4 - 2616.8 Torr;

DOI:10.1021/jm00088a011

upstream raw materials:

di-tert-butyl dicarbonate

(3S)-3-aminopyrrolidine

N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine

Benzyl (3R)-3-[(tert-butoxycarbonyl)amino]pyrrolidine-1-carboxylate

Downstream raw materials:

C₁₆H₂₀F₃N₃O₄

C₁₆H₂₁N₃O₂

(S)-tert-butyl (1-benzoylpyrrolidin-3-yl)(methyl)carbamate

(S)-tert-butyl (1-(2-hydroxyethyl)pyrrolidin-3-yl)carbamate

Refernces

• 1、 Pouliquen, Mickael,Blanchet, Jerome,Paolis, Michael De,Rema Devi,Rouden, Jacques,Lasne, Marie-Claire,Maddaluno, Jacques. "Chiral 3-aminopyrrolidines as a rigid diamino scaffold for organocatalysis and organometallic chemistry". experimental part. p. 1511 - 1521. Retrieved 2010/11/02.
• 2、 -. "NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME". Page/Page column 76; 81; 162-163; 168. . Retrieved 2008/12/05.