1,2-diamino-3,5-dimethoxybenzene

Base Information

• Chemical Name: 1,2-diamino-3,5-dimethoxybenzene
• CAS No.: 1075748-44-5
• Molecular Formula: C₈H₁₂N₂O₂
• Molecular Weight: 168.195
• Mol file: 1075748-44-5.mol

Synonyms:

Chemical Property of 1,2-diamino-3,5-dimethoxybenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dimethoxybenzene-1,2-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-diamino-3,5-dimethoxybenzene

There total 6 articles about 1,2-diamino-3,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3,5-Dimethoxy-2-nitrobenzenamine (192696-43-8) → 1,2-diamino-3,5-dimethoxybenzene (1075748-44-5)

Guidance literature:

With Pd/C (30%); hydrazine hydrate; In ethanol; for 2.5h; Reagent/catalyst; Inert atmosphere; Reflux;

DOI:10.3987/COM-20-14278

Reference yield:

N-(3,5-dimethoxyphenyl)formamide (1353562-24-9) → 1,2-diamino-3,5-dimethoxybenzene (1075748-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; acetic anhydride / water / 49 h / -10 - 0 °C

2: hydrazine hydrate; Pd/C (30%) / ethanol / 2.5 h / Inert atmosphere; Reflux

With Pd/C (30%); nitric acid; acetic anhydride; hydrazine hydrate; In ethanol; water;

DOI:10.3987/COM-20-14278

Reference yield:

N-(3,5-dimethoxy-2-nitrophenyl)formamide → 1,2-diamino-3,5-dimethoxybenzene (1075748-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / water; methanol / 0.25 h / Reflux

2: hydrazine hydrate; Pd/C (30%) / ethanol / 2.5 h / Inert atmosphere; Reflux

With Pd/C (30%); hydrazine hydrate; potassium hydroxide; In methanol; ethanol; water;

DOI:10.3987/COM-20-14278

upstream raw materials:

3,5-Dimethoxy-2-nitrobenzenamine

Acide 2-nitro-3,5-dimethoxybenzoique

3,5-dimethoxy-2-nitrobenzoyl chloride

N-(3,5-dimethoxyphenyl)formamide

Refernces

• 1、 Rewcastle, Gordon W.,Gamage, Swarna A.,Flanagan, Jack U.,Frederick, Raphael,Denny, William A.,Baguley, Bruce C.,Kestell, Philip,Singh, Ripudaman,Kendall, Jackie D.,Marshall, Elaine S.,Lill, Claire L.,Lee, Woo-Jeong,Kolekar, Sharada,Buchanan, Christina M.,Jamieson, Stephen M. F.,Shepherd, Peter R.. "Synthesis and biological evaluation of novel analogues of the pan class i phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474)". experimental part. p. 7105 - 7126. Retrieved 2011/12/04.
• 2、 -. "Imidazoquinoxaline protein tyrosine kinase inhibitors". . . Retrieved 2008/06/13.