2(5H)-Furanone, 4-[(1R)-1,2-dihydroxyethyl]-5-(hydroxymethyl)-, (5R)-

Base Information

Chemical Name:2(5H)-Furanone, 4-[(1R)-1,2-dihydroxyethyl]-5-(hydroxymethyl)-, (5R)-
CAS No.:506418-11-7
Molecular Formula:C₇H₁₀O₅
Molecular Weight:174.153
Hs Code.:
DSSTox Substance ID:DTXSID701157958

Synonyms:DTXSID701157958;2(5H)-Furanone, 4-[(1R)-1,2-dihydroxyethyl]-5-(hydroxymethyl)-, (5R)-;506418-11-7

Suppliers and Price of 2(5H)-Furanone, 4-[(1R)-1,2-dihydroxyethyl]-5-(hydroxymethyl)-, (5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(5H)-Furanone, 4-[(1R)-1,2-dihydroxyethyl]-5-(hydroxymethyl)-, (5R)-

Chemical Property:

XLogP3:-2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:174.05282342
Heavy Atom Count:12
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C(OC1=O)CO)C(CO)O
Isomeric SMILES:C1=C([C@@H](OC1=O)CO)[C@H](CO)O

Technology Process of 2(5H)-Furanone, 4-[(1R)-1,2-dihydroxyethyl]-5-(hydroxymethyl)-, (5R)-

There total 4 articles about 2(5H)-Furanone, 4-[(1R)-1,2-dihydroxyethyl]-5-(hydroxymethyl)-, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 506418-14-0
ethyl 3,3-bis[(4R)-2,2-diethyl-1,3-dioxolan-4-yl]propenoate

: 506418-11-7
(5R)-4-[(1R)-1,2-(dihydroxy)ethyl]-5-hydroxymethylfuran-2-(5H)-one

Guidance literature:: With camphor-10-sulfonic acid; water; In methanol; at 20 ℃; for 48h;
DOI:10.1021/jo026696r

Reference yield:

: 7643-75-6
L-(-)-arabitol

: 506418-11-7
(5R)-4-[(1R)-1,2-(dihydroxy)ethyl]-5-hydroxymethylfuran-2-(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: camphorsulfonic acid / tetrahydrofuran / 0.08 h / Heating

1.2: 74 percent / Et₃N / CH₂Cl₂ / 1 h / Heating

2.1: 99 percent / SO₃*pyridine; Et₃N / CH₂Cl₂; dimethylsulfoxide / 6 h / 0 °C

3.1: 98 percent / toluene / 1 h / Heating

4.1: 95 percent / camphorsulfonic acid; H₂O / methanol / 48 h / 20 °C

With pyridine-SO₃ complex; camphor-10-sulfonic acid; water; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene; 2.1: Parikh-Doering oxidation;
DOI:10.1021/jo026696r

Reference yield:

: 506418-13-9
(2S,4S)-1,2:4,5-bis(3,3-pentylidenedioxy)-3-pentanone

: 506418-11-7
(5R)-4-[(1R)-1,2-(dihydroxy)ethyl]-5-hydroxymethylfuran-2-(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / toluene / 1 h / Heating

2: 95 percent / camphorsulfonic acid; H₂O / methanol / 48 h / 20 °C

With camphor-10-sulfonic acid; water; In methanol; toluene;
DOI:10.1021/jo026696r