trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile

Base Information

Chemical Name:trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile
CAS No.:1344145-38-5
Molecular Formula:C₁₀H₈F₂N₂
Molecular Weight:194.184
Hs Code.:

Synonyms:

Suppliers and Price of trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
cis-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutane-1-carbonitrile
10mg
$ 45.00

American Custom Chemicals Corporation
CIS-3-FLUORO-1-(3-FLUOROPYRIDIN-2-YL)CYCLOBUTANE-1-CARBONITRILE 95.00%
5MG
$ 456.59

Activate Scientific
cis-3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutane-1-carbonitrile 95+%
1 g
$ 783.00

Activate Scientific
cis-3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutane-1-carbonitrile 95+%
250 mg
$ 356.00

Total 5 raw suppliers

Chemical Property of trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

cis-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutane-1-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile

There total 28 articles about trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1-(3-fluoropyridin-2-yl)-3-hydroxycyclobutane-1-carbonitrile

: 1344145-38-5
trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 10 ℃; for 6h;
DOI:10.1021/acs.jmedchem.1c01067

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1344145-38-5
trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / 0 - 20 °C

2: sodium periodate; ruthenium(III) trichloride hydrate / dichloromethane; acetonitrile; water / 10 - 30 °C

3: sodium tetrahydroborate / dichloromethane; methanol / 1 h / -78 °C

4: diethylamino-sulfur trifluoride / dichloromethane / 6 h / 0 - 10 °C

With sodium tetrahydroborate; sodium periodate; diethylamino-sulfur trifluoride; ruthenium(III) trichloride hydrate; sodium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.1c01067

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1344145-38-5
trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile

: 1344145-38-5
C₁₀H₈F₂N₂

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / 0 - 20 °C

2: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; water; dichloromethane / 10 - 20 °C

3: sodium tetrahydroborate; methanol / dichloromethane / 1 h / -78 °C

4: diethylamino-sulfur trifluoride / dichloromethane / 6 h / 0 °C / Reflux

With methanol; sodium tetrahydroborate; sodium periodate; diethylamino-sulfur trifluoride; ruthenium(III) trichloride hydrate; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;