Technology Process of urolithin M6
There total 9 articles about urolithin M6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
for 30h;
DOI:10.1021/acs.joc.7b00256
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide / acetonitrile / 4 h / 20 °C / Inert atmosphere
2: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dichloro-ethane / 24 h / 120 °C / Sealed tube; Inert atmosphere
3: sodium hydroxide / ethanol / 60 °C
4: N-iodo-succinimide / 1,2-dichloro-ethane / 3 h / 74 °C / Inert atmosphere
5: boron tribromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
With
potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); boron tribromide; sodium hydroxide;
In
ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
2: |Suzuki Coupling;
DOI:10.1039/c6ob01977c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dichloro-ethane / 24 h / 120 °C / Sealed tube; Inert atmosphere
2: sodium hydroxide / ethanol / 60 °C
3: N-iodo-succinimide / 1,2-dichloro-ethane / 3 h / 74 °C / Inert atmosphere
4: boron tribromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
With
potassium phosphate; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); boron tribromide; sodium hydroxide;
In
ethanol; dichloromethane; 1,2-dichloro-ethane;
1: |Suzuki Coupling;
DOI:10.1039/c6ob01977c
