Boc-D-Val-Ψ[(Z)CF=CH]-Gly-Gly-OEt

Base Information

• Chemical Name: Boc-D-Val-Ψ[(Z)CF=CH]-Gly-Gly-OEt
• CAS No.: 1147117-58-5
• Molecular Formula: C₁₇H₂₉FN₂O₅
• Molecular Weight: 360.426
• Mol file: 1147117-58-5.mol

Synonyms:

Chemical Property of Boc-D-Val-Ψ[(Z)CF=CH]-Gly-Gly-OEt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-D-Val-Ψ[(Z)CF=CH]-Gly-Gly-OEt

There total 2 articles about Boc-D-Val-Ψ[(Z)CF=CH]-Gly-Gly-OEt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C19H35F2NO3Si + glycine ethyl ester hydrochloride (623-33-6) → Boc-D-Val-Ψ[(Z)CF=CH]-Gly-Gly-OEt (1147117-58-5)

Guidance literature:

C₁₉H₃₅F₂NO₃Si; With potassium cyanide; 18-crown-6 ether; In N,N-dimethyl-formamide; at 0 ℃;

glycine ethyl ester hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 2h; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/jo900135t

Reference yield:

C19H35F2NO3Si + glycine ethyl ester hydrochloride (623-33-6) → Boc-D-Val-Ψ[(E)CF=CH]-Gly-Gly-OEt (1147117-59-6) + Boc-D-Val-Ψ[(Z)CF=CH]-Gly-Gly-OEt (1147117-58-5)

Guidance literature:

C₁₉H₃₅F₂NO₃Si; With potassium cyanide; 18-crown-6 ether; In tetrahydrofuran; at 0 ℃;

glycine ethyl ester hydrochloride; With triethylamine; In tetrahydrofuran; at 0 ℃; for 2h; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/jo900135t

upstream raw materials:

glycine ethyl ester hydrochloride

Refernces