2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one

Base Information

• Chemical Name: 2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one
• CAS No.: 1427413-65-7
• Molecular Formula: C₈H₅Br₂FO
• Molecular Weight: 295.934
• Hs Code.: 2909309090

Synonyms:

Chemical Property of 2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one

Chemical Property:

• Boiling Point: 301.6±32.0 °C(Predicted)
• Density: 1.914±0.06 g/cm3(Predicted)

Purity/Quality:

≥95% ^*data from raw suppliers

5-Bromo-2-fluorophenacylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one

There total 2 articles about 2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(5-bromo-2-fluorophenyl)ethan-1-one (198477-89-3) → 2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one (1427413-65-7)

Guidance literature:

With bromine; In dichloromethane; at 10 - 20 ℃; for 6h; Reagent/catalyst; Temperature;

Reference yield:

C8H4Br3FO → 2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one (1427413-65-7)

Guidance literature:

With sodium hydrogensulfite; In water; at 20 - 30 ℃; for 2h; Large scale;

DOI:10.1021/acs.oprd.9b00471

Reference yield:

2-bromo-1-(5-bromo-2-fluorophenyl)ethan-1-one (1427413-65-7) → N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide hydrochloride

Guidance literature:

Multi-step reaction with 17 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 4 h / 40 °C / Large scale

2.1: titanium(IV) isopropylate / toluene / 2 h / 90 °C / Large scale

3.1: trifluoroacetic acid / dichloromethane / 6 h / 33 - 43 °C / Large scale

4.1: hydrogenchloride / ethyl acetate; water / Large scale

5.1: sodium carbonate / dichloromethane; water / pH > 9 / Large scale

5.2: 3 h / 40 - 50 °C / Large scale

6.1: ethanol / 3 h / 65 - 75 °C / Large scale

7.1: hydrogenchloride / ethyl acetate; water / 1 h / 0 °C

8.1: tetrahydrofuran / 1 h / 0 - 25 °C

9.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 20 - 30 °C

9.2: 2 h

10.1: sodium carbonate / ethyl acetate; water

10.2: 8 h / 100 °C / Molecular sieve

11.1: sodium hydroxide; water / dichloromethane / 68 h / 24 °C

11.2: 1 h / 25 °C

12.1: triethylamine / dichloromethane / 1 h / 20 - 25 °C

13.1: triphenylphosphine; 1,3-dimethylbarbituric acid; palladium diacetate / dichloromethane / 1 h / 20 - 30 °C

14.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 - 85 °C

15.1: lithium hydroxide / methanol / 4 h / 60 - 70 °C

16.1: ammonium hydroxide / acetonitrile / pH 9

16.2: 3 h / 50 - 55 °C

17.1: hydrogenchloride / dichloromethane; diethyl ether

With titanium(IV) isopropylate; hydrogenchloride; ammonium hydroxide; 1,3-dimethylbarbituric acid; di-tert-butyl-diazodicarboxylate; water; palladium diacetate; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

1-(5-bromo-2-fluorophenyl)ethan-1-one

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