1-(Morpholin-4-yl)-3-phenylpropan-2-amine

Base Information

• Chemical Name: 1-(Morpholin-4-yl)-3-phenylpropan-2-amine
• CAS No.: 1021146-87-1
• Molecular Formula: C₁₃H₂₀N₂O
• Molecular Weight: 220.315
• European Community (EC) Number: 878-083-5
• Nikkaji Number: J3.346.607B
• Mol file: 1021146-87-1.mol

Synonyms:1-(morpholin-4-yl)-3-phenylpropan-2-amine;1021146-87-1;1-morpholin-4-yl-3-phenylpropan-2-amine;SCHEMBL5913859;AKOS000257539;AKOS024152165;CS-0259883;EN300-74318;(1-(4-Morpholinyl)-3-phenylpropane-2-yl)amine;Z335286660

Chemical Property of 1-(Morpholin-4-yl)-3-phenylpropan-2-amine

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 220.157563266
• Heavy Atom Count: 16
• Complexity: 186

Purity/Quality:

97% ^*data from raw suppliers

1-(Morpholin-4-yl)-3-phenylpropan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1CC(CC2=CC=CC=C2)N

Technology Process of 1-(Morpholin-4-yl)-3-phenylpropan-2-amine

There total 11 articles about 1-(Morpholin-4-yl)-3-phenylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(phenylalanyl)morpholine (141834-13-1) → (2S)-1-(morpholin-4-yl)-3-phenylpropan-2-amine (1021146-87-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1039/c2ob25922b

Reference yield: 62.0%

morpholine (110-91-8,99108-56-2) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (2S)-1-(morpholin-4-yl)-3-phenylpropan-2-amine (1021146-87-1)

Guidance literature:

morpholine; N-tert-butoxycarbonyl-L-phenylalanine; With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Cooling with ice;

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1039/c0ob00898b

Reference yield:

morpholine (110-91-8,99108-56-2) + (R)-2-(tert-butoxycarbonyl)-3-phenylpropyl 4-methylbenzenesulfonate (1057253-66-3) → (R)-1-morpholino-3-phenylpropan-2-amine (791777-59-8,1021146-87-1)

Guidance literature:

morpholine; (R)-2-(tert-butoxycarbonyl)-3-phenylpropyl 4-methylbenzenesulfonate; In acetonitrile; at 70 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 2h;

upstream raw materials:

(S)-tert-butyl 1-morpholino-3-phenylpropan-2-ylcarbamate

morpholine

N-tert-butoxycarbonyl-L-phenylalanine

N-Cbz-L-Phe