Technology Process of 5-Hydroxy-3-Methoxy-Naphthalene-2-Carboxylic Acid Methyl Ester
There total 4 articles about 5-Hydroxy-3-Methoxy-Naphthalene-2-Carboxylic Acid Methyl Ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 25 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / 25 °C / Industrial scale
2.1: 1H-imidazole / 1,2-dichloro-ethane / 0.75 h / 45 °C / Inert atmosphere
2.2: 2 h / 65 °C / Inert atmosphere
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 25 - 80 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C
With
1H-imidazole; thionyl chloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine;
In
tetrahydrofuran; 1,2-dichloro-ethane;
1.1: |Fischer-Speier Esterification / 3.1: |Mitsunobu Displacement;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1H-imidazole / 1,2-dichloro-ethane / 0.75 h / 45 °C / Inert atmosphere
1.2: 2 h / 65 °C / Inert atmosphere
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 25 - 80 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C
With
1H-imidazole; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine;
In
tetrahydrofuran; 1,2-dichloro-ethane;
2.1: |Mitsunobu Displacement;
