1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)

Base Information

• Chemical Name: 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)
• CAS No.: 105462-25-7
• Molecular Formula: C₇H₁₁NO₇P₂
• Molecular Weight: 283.114
• Mol file: 105462-25-7.mol

Synonyms:

Chemical Property of 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)

Chemical Property:

• Melting Point: >236°C (dec.)
• Boiling Point: 694.7±65.0 °C(Predicted)
• Density: 1.870±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

P,P''-[1-Hydroxy-2-(4-pyridinyl)ethylidene]bis-phosphonicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: P,P''-[1-Hydroxy-2-(4-pyridinyl)ethylidene]bis-phosphonic Acid is used in biological studies for bisphosphonates preparation as it has Trypanosoma cruzi hexokinase inhibition properties.

Technology Process of 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)

There total 2 articles about 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

pyridine-4-acetic acid (28356-58-3) → 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid) (105462-25-7)

Guidance literature:

pyridine-4-acetic acid; With 4-nitro-phenol; phosphoric acid; phosphorus trichloride; Heating;

With water; Further stages.; Heating;

DOI:10.1080/00397910701578545

Reference yield:

2-(pyridine-4-yl)acetic acid hydrochloride (6622-91-9) → 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid) (105462-25-7)

Guidance literature:

2-(pyridine-4-yl)acetic acid hydrochloride; With phosphoric acid; phosphorus trichloride; In sulfolane; at 80 ℃; for 0.1h; Microwave irradiation;

With water; In sulfolane; at 150 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid) (105462-25-7) → C37H48N3O18P2(1+)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; water

2: trifluoroacetic acid / water

3: trifluoroacetic acid; tetraethylammonium bromide / tetrahydrofuran; N,N-dimethyl-formamide / 50 °C / pH 7

With tetraethylammonium bromide; trifluoroacetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

pyridine-4-acetic acid

2-(pyridine-4-yl)acetic acid hydrochloride