2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole

Base Information

• Chemical Name: 2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole
• CAS No.: 1192019-22-9
• Molecular Formula: C₁₅H₁₁F₃N₂O
• Molecular Weight: 292.26
• Mol file: 1192019-22-9.mol

Synonyms:

Chemical Property of 2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Ethylpyridin-4-yl)-5-(trifluoromethyl)benzo[d]oxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole

There total 6 articles about 2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-ethynylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole (1282541-01-8) → 2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole (1192019-22-9)

Guidance literature:

With hydrogen; 5% Pd(II)/C(eggshell); In ethyl acetate; at 20 ℃; for 2h; under 760.051 Torr;

Reference yield:

methyl 3-iodo-4-pyridinecarboxylate (188677-49-8) → 2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole (1192019-22-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / 3 h / 60 °C

1.2: pH 2 - 3 / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 0.25 h / 50 °C

2.2: 2 h / 80 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 50 °C

4.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C

5.1: potassium carbonate; methanol / 1 h / 20 °C

6.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 1 h / 20 °C / 760.05 Torr

With pyridine; methanol; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5% Pd(II)/C(eggshell); In tetrahydrofuran; ethyl acetate; toluene;

Reference yield:

3-iodo-4-pyridinecarboxylic acid (57842-10-1) → 2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole (1192019-22-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 0.25 h / 50 °C

1.2: 2 h / 80 °C

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 50 °C

3.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C

4.1: potassium carbonate; methanol / 1 h / 20 °C

5.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 1 h / 20 °C / 760.05 Torr

With pyridine; methanol; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5% Pd(II)/C(eggshell); In tetrahydrofuran; ethyl acetate; toluene;

upstream raw materials:

2-(3-ethynylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole

methyl 3-iodo-4-pyridinecarboxylate

3-iodo-4-pyridinecarboxylic acid

N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-iodoisonicotinamide

Refernces

• 1、 -. "HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND". Page/Page column 46. . Retrieved 2011/04/13.
• 2、 -. "COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS". Page/Page column 127-128. . Retrieved 2011/05/06.