Bicyclo[2.2.2]octan-1-amine hydrochloride

Base Information

• Chemical Name: Bicyclo[2.2.2]octan-1-amine hydrochloride
• CAS No.: 1193-43-7
• Molecular Formula: C₈H₁₅N*ClH
• Molecular Weight: 161.675
• Hs Code.: 2921309990
• European Community (EC) Number: 830-270-2
• Mol file: 1193-43-7.mol

Synonyms:Bicyclo[2.2.2]octan-1-amine hydrochloride;1193-43-7;bicyclo[2.2.2]octan-1-amine;hydrochloride;bicyclo[2.2.2]octan-1-amine hcl;MFCD28009517;1-aminobicyclo[2.2.2]octane hydrochloride;SCHEMBL23141228;KRLMHOAIQRMILW-UHFFFAOYSA-N;BAA19343;Bicyclo[2.2.2]octane-1-Amine HCl;AKOS037643833;SB12137;AS-37604;SY206521;Bicyclo[2.2.2]octan-1-aminehydrochloride;CS-0049785;EN300-234103;Z2235681455

Chemical Property of Bicyclo[2.2.2]octan-1-amine hydrochloride

Chemical Property:

• Boiling Point: 120-121 °C(Press: 200 Torr)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 161.0971272
• Heavy Atom Count: 10
• Complexity: 98

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bicyclo[2.2.2]octan-1-aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC2(CCC1CC2)N.Cl

Technology Process of Bicyclo[2.2.2]octan-1-amine hydrochloride

There total 4 articles about Bicyclo[2.2.2]octan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-bicyclo<2.2.2>oct-1-ylacetamide (63707-73-3) → 1-bicyclo<2.2.2>octylammonium chloride (1193-43-7)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

DOI:10.1021/jo00302a019

Reference yield:

norbornane-1-carboxylic acid (18720-30-4) → 1-bicyclo<2.2.2>octylammonium chloride (1193-43-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / LiAlH₄ / diethyl ether

2: 5.7 g / fuming sulfuric acid, conc. H₂SO₄

3: 99 percent / conc. HCl / 16 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; In diethyl ether;

DOI:10.1021/jo00302a019

Reference yield:

exo,endo-2-bromobicyclo<2.2.1>heptane-1-carboxylic acid (74830-47-0) → 1-bicyclo<2.2.2>octylammonium chloride (1193-43-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / tri-n-butyltin hydride

2: 92 percent / LiAlH₄ / diethyl ether

3: 5.7 g / fuming sulfuric acid, conc. H₂SO₄

4: 99 percent / conc. HCl / 16 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; tri-n-butyl-tin hydride; In diethyl ether;

DOI:10.1021/jo00302a019

upstream raw materials:

N-bicyclo<2.2.2>oct-1-ylacetamide

1-(Hydroxymethyl)bicyclo<2.2.1>heptane

norbornane-1-carboxylic acid

exo,endo-2-bromobicyclo<2.2.1>heptane-1-carboxylic acid

Downstream raw materials:

trans-N,N'-bis(bicyclo<2.2.2>oct-1-yl)diazene