C₂₃H₁₈ClNO₄

Base Information

• Chemical Name: C₂₃H₁₈ClNO₄
• CAS No.: 1260590-28-0
• Molecular Formula: C₂₃H₁₈ClNO₄
• Molecular Weight: 407.853
• Mol file: 1260590-28-0.mol

Synonyms:

Chemical Property of C₂₃H₁₈ClNO₄

Chemical Property:

• Boiling Point: 632.0±55.0 °C(Predicted)
• Density: 1.362±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Fmoc-L-Phg(4-Cl)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₁₈ClNO₄

There total 2 articles about C₂₃H₁₈ClNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (R)-2-amino-2-(4-chlorophenyl)acetic acid (43189-37-3,7292-70-8) → C23H18ClNO4 (1260590-28-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b01796

Reference yield: 100.0%

→ C23H18ClNO4 (1260590-28-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; at 20 ℃;

Reference yield:

C23H18ClNO4 (1260590-28-0) → C43H61ClN8O8S

Guidance literature:

Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 4 h / 20 °C

2: diethylamine / acetonitrile / 4 h / 40 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 4 h / 20 °C

4: diethylamine / acetonitrile / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

6: Hoveyda-Grubbs catalyst second generation / dichloromethane / 45 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; Hoveyda-Grubbs catalyst second generation; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1021/acs.jmedchem.6b01796

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(R)-2-amino-2-(4-chlorophenyl)acetic acid