(1R,2S)-1-Hydroxy-2-phenoxy-cyclopentanecarboxylic acid tert-butylamide

Base Information

Chemical Name:(1R,2S)-1-Hydroxy-2-phenoxy-cyclopentanecarboxylic acid tert-butylamide
CAS No.:78167-21-2
Molecular Formula:C₁₆H₂₃NO₃
Molecular Weight:277.364
Hs Code.:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-1-Hydroxy-2-phenoxy-cyclopentanecarboxylic acid tert-butylamide

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Technology Process of (1R,2S)-1-Hydroxy-2-phenoxy-cyclopentanecarboxylic acid tert-butylamide

There total 1 articles about (1R,2S)-1-Hydroxy-2-phenoxy-cyclopentanecarboxylic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 78726-16-6
2-phenoxycyclopentanone

: 78167-21-2
(1R,2S)-1-Hydroxy-2-phenoxy-cyclopentanecarboxylic acid tert-butylamide

Guidance literature:: With pyridine; sodium hydrogencarbonate; trifluoroacetic acid; Yield given. Multistep reaction; 1.) CH₂Cl₂, room temp., 3.5 h; 2.) room temp., 2 h;
DOI:10.1021/jo00331a017

Reference yield:

: 78167-21-2
(1R,2S)-1-Hydroxy-2-phenoxy-cyclopentanecarboxylic acid tert-butylamide

: 78167-25-6
(1S,2S)-1-(tert-Butylamino-methyl)-2-phenoxy-cyclopentanol

Guidance literature:: With dimethylsulfide borane complex; acetic acid; Yield given. Multistep reaction; 1.) THF, reflux, 5h; 2.) 0 deg C;
DOI:10.1021/jo00331a017