fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate

Base Information

• Chemical Name: fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate
• CAS No.: 1174034-79-7
• Molecular Formula: C₂₅H₃₁F₃O₆
• Molecular Weight: 484.513
• Mol file: 1174034-79-7.mol

Synonyms:

Chemical Property of fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Fluoromethyl(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: This is an impurity of Fluticasone (F599456), an inhaled corticosteroid used in the treatment of respiratory diseases.

Technology Process of fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate

There total 1 articles about fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

iodomethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate (1174034-78-6) → fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate (1174034-79-7)

Guidance literature:

With silver fluoride; In acetonitrile; at 20 ℃; for 3h; Darkness;

DOI:10.1080/00304940809458122

upstream raw materials:

iodomethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylate