N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

Base Information

• Chemical Name: N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide
• CAS No.: 857290-04-1
• Molecular Formula: C₁₈H₁₄N₄O₂S
• Molecular Weight: 350.401
• Mol file: 857290-04-1.mol

Synonyms:

Chemical Property of N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

Chemical Property:

• Vapor Pressure: 7.27E-15mmHg at 25°C
• Boiling Point: 610.9±65.0 °C(Predicted)
• PKA: 7.97±0.29(Predicted)
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: Store at RT

Purity/Quality:

97% ^*data from raw suppliers

PF 915275 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

There total 4 articles about N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H22N4O4S (1174670-65-5) → 4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide (857290-04-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 70 ℃;

DOI:10.1016/j.bmcl.2009.05.011

Reference yield:

4-cyano-1,1'-biphenyl (2920-38-9) → 4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide (857290-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chlorosulfonic acid / dichloromethane / 10 °C

1.3: 106 °C

2.1: pyridine / dichloromethane

With pyridine; chlorosulfonic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2013.02.066

Reference yield:

4'-cyano[1,1'-biphenyl]-4-sulfonyl chloride (149506-86-5) + 2.6-diaminopyridine (141-86-6) → 4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide (857290-04-1)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/j.bmcl.2013.02.066

upstream raw materials:

C₂₃H₂₂N₄O₄S

4'-cyano[1,1'-biphenyl]-4-sulfonyl chloride

2.6-diaminopyridine

4-cyano-1,1'-biphenyl