(1R,2S)-2-phenylcyclopropanaminium (1S,2R)-2-phenylcyclopropanaminium sulfate (1:1:1)

Base Information

• Chemical Name: (1R,2S)-2-phenylcyclopropanaminium (1S,2R)-2-phenylcyclopropanaminium sulfate (1:1:1)
• CAS No.: 7081-36-9
• Molecular Formula: 2C₉H₁₁N*H₂O₄S
• Molecular Weight: 364.466
• Mol file: 7081-36-9.mol

Synonyms:

Chemical Property of (1R,2S)-2-phenylcyclopropanaminium (1S,2R)-2-phenylcyclopropanaminium sulfate (1:1:1)

Chemical Property:

• Vapor Pressure: 0.127mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-phenylcyclopropanaminium (1S,2R)-2-phenylcyclopropanaminium sulfate (1:1:1)

There total 4 articles about (1R,2S)-2-phenylcyclopropanaminium (1S,2R)-2-phenylcyclopropanaminium sulfate (1:1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S)-2-Phenyl-cyclopropanecarbonyl azide → Parnate (13492-01-8,1949-18-4,3548-91-2,7081-36-9)

Guidance literature:

(1S,2S)-2-Phenyl-cyclopropanecarbonyl azide; With hydrogenchloride; In water; Cooling with ice;

With sulfuric acid; In ethanol; isopropyl alcohol; pH=2; Cooling with ice;

DOI:10.1007/s11164-016-2572-1

Reference yield:

(1SR,2SR)-2-phenylcyclopropanecarbonyl chloride (939-87-7,5685-36-9,37107-48-5,42916-08-5,42916-12-1,42916-13-2,62624-90-2,78738-39-3) → Parnate (13492-01-8,1949-18-4,3548-91-2,7081-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide / toluene / 4 h / 80 °C / Reflux

2.1: hydrogenchloride / water / Cooling with ice

2.2: pH 2 / Cooling with ice

With hydrogenchloride; sodium azide; In water; toluene;

DOI:10.1007/s11164-016-2572-1

Reference yield:

(E)-3-phenylacrylic acid (140-10-3) → Parnate (13492-01-8,1949-18-4,3548-91-2,7081-36-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: CuCr₂O₄; 1-butyl-3-methylimidazolium hydroxide / tetrahydrofuran / 4 h / 20 - 50 °C

2.1: chloroformic acid ethyl ester; triethylamine / toluene / 4 h / Cooling with ice

3.1: sodium azide / toluene / 4 h / 80 °C / Reflux

4.1: hydrogenchloride / water / Cooling with ice

4.2: pH 2 / Cooling with ice

With 1-butyl-3-methylimidazolium hydroxide; hydrogenchloride; sodium azide; CuCr₂O₄; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; water; toluene;

DOI:10.1007/s11164-016-2572-1

upstream raw materials:

(1SR,2SR)-2-phenylcyclopropanecarbonyl chloride

(E)-3-phenylacrylic acid

trans-2-phenylcyclopropane-1-carboxylic acid

Downstream raw materials:

N-methyl-trans-2-phenylcyclopropylamine hydrochloride