(2S,3S,11bR)-Dihydrotetrabenazine

Base Information

Chemical Name:(2S,3S,11bR)-Dihydrotetrabenazine
CAS No.:862377-27-3
Molecular Formula:C₁₉H₂₉NO₃
Molecular Weight:319.444
Hs Code.:
European Community (EC) Number:948-387-3
UNII:1JDAHLD17U
ChEMBL ID:CHEMBL1770805

Synonyms:(2S,3S,11bR)-Dihydrotetrabenazine;862377-27-3;UNII-1JDAHLD17U;1JDAHLD17U;CHEMBL1770805;RUS-350;(2S,3S,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol;Trans (2,3)-Dihydrotetrabenazine;(2S,3S,11bR)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo(a)quinolizin-2-ol;(2S,3S,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol;2H-Benzo(a)quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bR)-;171598-74-6;SCHEMBL12532652;BDBM50342824;HY-15793A;AT21767;CS-1900;(2S,3S,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLIN-2-OL;(2S,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11bhexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

Suppliers and Price of (2S,3S,11bR)-Dihydrotetrabenazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,3S,11bR)-Dihydrotetrabenazine
25mg
$ 550.00

TRC
(2S,3S,11bR)-Dihydrotetrabenazine
10mg
$ 250.00

Total 6 raw suppliers

Chemical Property of (2S,3S,11bR)-Dihydrotetrabenazine

Chemical Property:

Boiling Point:457.8±45.0 °C(Predicted)
Density:1.13±0.1 g/cm3(Predicted)
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:319.21474379
Heavy Atom Count:23
Complexity:389

Purity/Quality:

98% ^*data from raw suppliers

(2S,3S,11bR)-Dihydrotetrabenazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1O)OC)OC
Isomeric SMILES:CC(C)C[C@H]1CN2CCC3=CC(=C(C=C3[C@H]2C[C@@H]1O)OC)OC
Uses (2S,3S,11bR)-Dihydrotetrabenazine is an enantiomer of?(2R,3R,11bS)-Dihydrotetrabenazine (D454910), which is a?vesicular monoamine transporter 2?(VMAT2)?inhibitor and can be used to treat asthma, anxiety and dementia.

Technology Process of (2S,3S,11bR)-Dihydrotetrabenazine

There total 8 articles about (2S,3S,11bR)-Dihydrotetrabenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 862287-31-8
C₂₉H₃₆F₃NO₅

: 862377-27-3
(2S,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

Guidance literature:: With methanol; sodium hydroxide; water; for 2.5h; Heating / reflux;

Reference yield: 41.0%

: 920265-21-0
(11bR)-1,6,7,11b-tetrahydro-9,10-dimethoxy-3-(2-methylpropyl)-4H-benzo[a]quinolizine

: 862377-27-3
(2S,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

Guidance literature:: (11bR)-1,6,7,11b-tetrahydro-9,10-dimethoxy-3-(2-methylpropyl)-4H-benzo[a]quinolizine; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 15 ℃; for 48h;

With water; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; for 1.5h; pH=12; Reflux;
DOI:10.1016/j.ejmech.2011.02.046

Reference yield:

: 862287-30-7
C₁₉H₂₇NO₂

: 862377-29-5
S,R,R-DHTBZ

: 862377-27-3
(2S,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

Guidance literature:: C₁₉H₂₇NO₂; With borane-THF; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; water; pH=12;

With dihydrogen peroxide; In tetrahydrofuran; water; for 1h; Heating / reflux;