Technology Process of 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c]pyridine-3-carboxamide
There total 13 articles about 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c]pyridine-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate; formamide;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 5h;
DOI:10.1016/j.bmc.2016.09.024
- Guidance literature:
-
Multi-step reaction with 10 steps
1: trimethylamine / tetrahydrofuran / 0 - 20 °C
2: potassium carbonate; dimethyl sulfoxide / 6 h / 80 °C
3: phosphorus pentachloride / dichloromethane / 5 h / Reflux
4: 1.5 h / 130 °C
5: trimethylamine / ethyl acetate / 6 h / 80 °C
6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
7: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C
8: trimethylamine / tetrahydrofuran / 6.5 h / 0 - 25 °C
9: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
10: sodium methylate; formamide / N,N-dimethyl-formamide / 5 h / 50 °C
With
hydrogenchloride; phosphorus pentachloride; sodium methylate; iron; sodium hydride; potassium carbonate; ammonium chloride; formamide; dimethyl sulfoxide; trifluoroacetic acid; trimethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.09.024
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium nitrite; hydrogenchloride / water / -5 - 20 °C
1.2: 2 h / 25 °C
2.1: trimethylamine / ethyl acetate / 6 h / 80 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4.1: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C
5.1: trimethylamine / tetrahydrofuran / 6.5 h / 0 - 25 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
7.1: sodium methylate; formamide / N,N-dimethyl-formamide / 5 h / 50 °C
With
hydrogenchloride; sodium methylate; iron; sodium hydride; ammonium chloride; formamide; trifluoroacetic acid; sodium nitrite; trimethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.09.024
