S-ethyl-2-thio-[5']isoguanylic acid

Base Information

• Chemical Name: S-ethyl-2-thio-[5']isoguanylic acid
• CAS No.: 66522-45-0
• Molecular Formula: C₁₂H₁₈N₅O₇PS
• Molecular Weight: 407.344
• Mol file: 66522-45-0.mol

Synonyms:

Chemical Property of S-ethyl-2-thio-[5']isoguanylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-ethyl-2-thio-[5']isoguanylic acid

There total 4 articles about S-ethyl-2-thio-[5']isoguanylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (16321-99-6) → S-ethyl-2-thio-[5']isoguanylic acid (66522-45-0,70804-86-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / isoamyl nitrite / acetonitrile / 20 h / 60 °C

2: aq. NH₃ / dioxane / 24 h / 95 °C

3: 1.) POCl₃, (Et₃O)3PO, 2.) aq. NaHCO₃ / 1.) 0 deg C, 5 h, 2.) 0 deg C, 45 min

With ammonium hydroxide; triethyl phosphate; sodium hydrogencarbonate; trichlorophosphate; isopentyl nitrite; In 1,4-dioxane; acetonitrile;

DOI:10.1021/jm981072s

Reference yield:

6-chloro-2-ethylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine (221552-84-7) → S-ethyl-2-thio-[5']isoguanylic acid (66522-45-0,70804-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃ / dioxane / 24 h / 95 °C

2: 1.) POCl₃, (Et₃O)3PO, 2.) aq. NaHCO₃ / 1.) 0 deg C, 5 h, 2.) 0 deg C, 45 min

With ammonium hydroxide; triethyl phosphate; sodium hydrogencarbonate; trichlorophosphate; In 1,4-dioxane;

DOI:10.1021/jm981072s

Reference yield:

2-(Ethylthio)adenosine (31528-52-6) → S-ethyl-2-thio-[5']isoguanylic acid (66522-45-0,70804-86-3)

Guidance literature:

With triethyl phosphate; sodium hydrogencarbonate; trichlorophosphate; Multistep reaction; 1.) 0 deg C, 5 h, 2.) 0 deg C, 45 min;

DOI:10.1021/jm981072s

upstream raw materials:

2-(Ethylthio)adenosine

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

6-chloro-2-ethylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine