DEPMPO-biotin

Base Information

• Chemical Name: DEPMPO-biotin
• CAS No.: 936224-52-1
• Molecular Formula: C₂₄H₄₂N₅O₈PS
• Molecular Weight: 591.666
• Mol file: 936224-52-1.mol

Synonyms:

Chemical Property of DEPMPO-biotin

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

DEPMPO-biotin ≥95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DEPMPO-biotin

There total 5 articles about DEPMPO-biotin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

5-diethoxyphosphoryl-4-succinimidyloxycarbonyloxymethyl-5-methyl-1-pyrroline-N-oxide + N-(+)-biotinyl-3-aminopropylammonium trifluoroacetate (244760-26-7) → btDEPMPO (936224-52-1)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1039/b616076j

Reference yield:

4-(1-diethoxyphosphoryl-1-nitroethyl)tetrahydrofuran-2-one (936021-23-7) → btDEPMPO (936224-52-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: Zn; ammonium chloride / tetrahydrofuran; H₂O / 20 °C

3: 95 percent / Et₃N / acetonitrile / 20 °C

4: 39 percent / Et₃N / dimethylsulfoxide / 20 °C

With ammonium chloride; diisobutylaluminium hydride; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

DOI:10.1039/b616076j

Reference yield:

4-(1-diethoxyphosphoryl-1-nitroethyl)-2-hydroxytetrahydrofuran (936021-24-8) → btDEPMPO (936224-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Zn; ammonium chloride / tetrahydrofuran; H₂O / 20 °C

2: 95 percent / Et₃N / acetonitrile / 20 °C

3: 39 percent / Et₃N / dimethylsulfoxide / 20 °C

With ammonium chloride; triethylamine; zinc; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile;

DOI:10.1039/b616076j

upstream raw materials:

N-(+)-biotinyl-3-aminopropylammonium trifluoroacetate

4-(1-diethoxyphosphoryl-1-nitroethyl)tetrahydrofuran-2-one

4-(1-diethoxyphosphoryl-1-nitroethyl)-2-hydroxytetrahydrofuran

(1-nitroethyl)-phosphonic acid diethyl ester