1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

Base Information

Chemical Name:1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride
CAS No.:140412-53-9
Molecular Formula:C₂₃H₂₉F₂N₅O₄*2ClH
Molecular Weight:550.433
Hs Code.:

1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

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Chemical Property of 1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

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Technology Process of 1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

There total 4 articles about 1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 140412-53-9,140412-54-0
1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylporpholine / CH₂Cl₂ / 0.08 h / -20 - -10 °C

2: CH₂Cl₂ / 0.5 h / -10 °C

3: H₂ / 20percent Pd/C / methanol / 3 h / 24.5 - 25.5 °C / 2518.5 - 2668.5 Torr

4: Et₃N / acetonitrile / 4 h / Heating

5: 1.0 M aq. HCl / ethanol / 1.) RT, 1 h, 2.) reflux, 2 h

With hydrogenchloride; N-methylporpholine; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00088a011

Reference yield:

: 259855-92-0
C₁₆H₃₀N₂O₆

: 140412-53-9,140412-54-0
1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0.5 h / -10 °C

2: H₂ / 20percent Pd/C / methanol / 3 h / 24.5 - 25.5 °C / 2518.5 - 2668.5 Torr

3: Et₃N / acetonitrile / 4 h / Heating

4: 1.0 M aq. HCl / ethanol / 1.) RT, 1 h, 2.) reflux, 2 h

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00088a011

Reference yield:

: 3-((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-pyrrolidine-1-carboxylic acid benzyl ester

: 140412-53-9,140412-54-0
1-Cyclopropyl-7-[3-((S)-2,6-diamino-hexanoylamino)-pyrrolidin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 20percent Pd/C / methanol / 3 h / 24.5 - 25.5 °C / 2518.5 - 2668.5 Torr

2: Et₃N / acetonitrile / 4 h / Heating

3: 1.0 M aq. HCl / ethanol / 1.) RT, 1 h, 2.) reflux, 2 h

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; acetonitrile;
DOI:10.1021/jm00088a011