NO-prednisolone

Base Information

Chemical Name:NO-prednisolone
CAS No.:327610-87-7
Molecular Formula:C₂₉H₃₃NO₉
Molecular Weight:539.582
Hs Code.:
UNII:EZB76EP46E

Synonyms:21-NO-prednisolone;NCX 1015;NCX-1015;NCX1015;prednisolone 21-((4'-nitrooxymethyl)benzoate)

Suppliers and Price of NO-prednisolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of NO-prednisolone

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:539.21553163
Heavy Atom Count:39
Complexity:1100

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12CC(C3C(C1CCC2(C(=O)COC(=O)C4=CC=C(C=C4)CO[N+](=O)[O-])O)CCC5=CC(=O)C=CC35C)O
Isomeric SMILES:C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COC(=O)C4=CC=C(C=C4)CO[N+](=O)[O-])O)CCC5=CC(=O)C=C[C@]35C)O

Technology Process of NO-prednisolone

There total 3 articles about NO-prednisolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: prednisolone 21-[4'-(chloromethyl)benzoate]

: 327610-87-7
prednisolone 21-[(4’-nitro-oxymethyl)benzoate]

Guidance literature:: With silver nitrate; In tetrahydrofuran; acetonitrile; for 4h; Heating;
DOI:10.1021/jm030964b

Reference yield:

: 50-24-8,8056-11-9
prednisolon

: 327610-87-7
prednisolone 21-[(4’-nitro-oxymethyl)benzoate]

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Et₃N / tetrahydrofuran / 18 h / 20 °C

2: 54 percent / AgNO₃ / acetonitrile; tetrahydrofuran / 4 h / Heating

With silver nitrate; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm030964b

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 327610-87-7
prednisolone 21-[(4’-nitro-oxymethyl)benzoate]

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Et₃N / tetrahydrofuran / 18 h / 20 °C

2: 54 percent / AgNO₃ / acetonitrile; tetrahydrofuran / 4 h / Heating

With silver nitrate; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm030964b