bicyclo[1.1.1]pentane-1-sulfonamide

Base Information

• Chemical Name: bicyclo[1.1.1]pentane-1-sulfonamide
• CAS No.: 2413074-53-8
• Molecular Formula: C₅H₉NO₂S
• Molecular Weight: 147.198
• Mol file: 2413074-53-8.mol

Synonyms:

Chemical Property of bicyclo[1.1.1]pentane-1-sulfonamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bicyclo[1.1.1]pentane-1-sulfonamide

There total 4 articles about bicyclo[1.1.1]pentane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

sodium bicyclo[1.1.1]pentanesulfinate → bicyclo[1.1.1]pentane-1-sulfonamide (2413074-53-8)

Guidance literature:

With potassium acetate; hydroxylamine-O-sulfonic acid; In water; at 20 ℃;

DOI:10.1002/chem.202000097

Reference yield:

[1.1.1]propellane (35634-10-7) → bicyclo[1.1.1]pentane-1-sulfonamide (2413074-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether / 0.5 h / 20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C

3: sodium methylate / tetrahydrofuran; methanol / 0.33 h / 20 °C

4: hydroxylamine-O-sulfonic acid; potassium acetate / water / 20 °C

With sodium methylate; potassium acetate; 3-chloro-benzenecarboperoxoic acid; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;

DOI:10.1002/chem.202000097

Reference yield:

C9H14O2S → bicyclo[1.1.1]pentane-1-sulfonamide (2413074-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C

2: sodium methylate / tetrahydrofuran; methanol / 0.33 h / 20 °C

3: hydroxylamine-O-sulfonic acid; potassium acetate / water / 20 °C

With sodium methylate; potassium acetate; 3-chloro-benzenecarboperoxoic acid; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1002/chem.202000097

upstream raw materials:

[1.1.1]propellane