MMP-9/MMP-13 INHIBITOR I

Base Information

Chemical Name:MMP-9/MMP-13 INHIBITOR I
CAS No.:204140-01-2
Molecular Formula:C₂₅H₂₅N₃O₆S
Molecular Weight:495.556
Hs Code.:
Mol file:204140-01-2.mol

Synonyms:

Suppliers and Price of MMP-9/MMP-13 INHIBITOR I

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
MMP-9/MMP-13 Inhibitor I ≥98%
500μg
$ 59.00

Cayman Chemical
MMP-9/MMP-13 Inhibitor I ≥98%
1mg
$ 105.00

Alfa Aesar
MMP-9/MMP-13 Inhibitor I
1mg
$ 99.60

AK Scientific
MMP-9/MMP-13 Inhibitor I
1mg
$ 241.00

Total 9 raw suppliers

Chemical Property of MMP-9/MMP-13 INHIBITOR I

Chemical Property:

Storage Temp.:-20°C
Sensitive.:Light Sensitive
Solubility.:Soluble in DMSO or methanol

Purity/Quality:

≥98% ^*data from raw suppliers

MMP-9/MMP-13 Inhibitor I ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.
Uses A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13

Technology Process of MMP-9/MMP-13 INHIBITOR I

There total 3 articles about MMP-9/MMP-13 INHIBITOR I which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfonyl)-piperazine-2-carboxylic acid methyl ester

: 204140-01-2
N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide

Guidance literature:: With hydroxylamine; In methanol; at 20 ℃;
DOI:10.1021/jm990366q

Reference yield:

: 14002-51-8
4-biphenyl-carboxylic acid chloride

: 204140-01-2
N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; DMAP / dioxane; H₂O / 20 °C

2: NH₂OH / methanol / 20 °C

With dmap; hydroxylamine; triethylamine; In 1,4-dioxane; methanol; water; 1: Acylation / 2: carboxamidation;
DOI:10.1021/jm990366q

Reference yield:

: methyl 1-(4-methoxyphenyl)sulfonyl-4-(tert-butoxycarbonyl)piperazine-2-carboxylate hydrochloride

: 204140-01-2
N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; DMAP / dioxane; H₂O / 20 °C

2: NH₂OH / methanol / 20 °C

With dmap; hydroxylamine; triethylamine; In 1,4-dioxane; methanol; water; 1: Acylation / 2: carboxamidation;
DOI:10.1021/jm990366q