N-(8-quinolinyl)-1-piperidinesulfonamide

Base Information

• Chemical Name: N-(8-quinolinyl)-1-piperidinesulfonamide
• CAS No.: 927639-56-3
• Molecular Formula: C₁₄H₁₇N₃O₂S
• Molecular Weight: 291.374
• Mol file: 927639-56-3.mol

Synonyms:

Chemical Property of N-(8-quinolinyl)-1-piperidinesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(8-quinolinyl)-1-piperidinesulfonamide

There total 2 articles about N-(8-quinolinyl)-1-piperidinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

piperidine (110-89-4) + tert-butyl (N-(quinolin-8-yl)sulfamoyl)carbamate → N-(quinolin-8-yl)piperidine-1-sulfamide (927639-56-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 60 ℃; for 18h;

DOI:10.1016/j.bioorg.2021.104778

Reference yield:

8-amino quinoline (578-66-5) → N-(quinolin-8-yl)piperidine-1-sulfamide (927639-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / 0 °C

1.2: 1 h / 0 °C

2.1: triethylamine / tetrahydrofuran / 18 h / 60 °C

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bioorg.2021.104778

upstream raw materials:

piperidine

8-amino quinoline