1',3'-bis[1,2-diMyristoyl-sn-glycero-3-phospho]-sn-glycerol (aMMoniuM salt)

Base Information

• Chemical Name: 1',3'-bis[1,2-diMyristoyl-sn-glycero-3-phospho]-sn-glycerol (aMMoniuM salt)
• CAS No.: 63988-20-5
• Molecular Formula: C₆₅H₁₂₆O₁₇P₂*2H₃N
• Molecular Weight: 1275.71
• Mol file: 63988-20-5.mol

Synonyms:

Chemical Property of 1',3'-bis[1,2-diMyristoyl-sn-glycero-3-phospho]-sn-glycerol (aMMoniuM salt)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1'',?3''-1'',?3''-?bis[1,?2-?Dimyristoyl-?sn-?glycero-?3-?phospho]?-?glycerol Ammonium Salt is a PEGylated liposome-encapsulated glycopeptide antibiotic for treatment of bacterial infections.

Technology Process of 1',3'-bis[1,2-diMyristoyl-sn-glycero-3-phospho]-sn-glycerol (aMMoniuM salt)

There total 4 articles about 1',3'-bis[1,2-diMyristoyl-sn-glycero-3-phospho]-sn-glycerol (aMMoniuM salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,3-bis[(1,2-di-O-myristoyl-sn-glycero-3)-phosphoryl]-2-O-benzylglycerol diammonium salt → 1,3-bis[(1,2-di-O-myristoyl-sn-glycero-3)-phosphoryl]glycerol diammonium salt (63988-20-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 10h; under 2585.74 Torr;

DOI:10.1016/j.tet.2006.04.071

Reference yield: 86.0%

2-O-benzyl-1,3-bis(1,2-O-dimyristoyl-sn-glycero-3-phosphoryl)glycerol diammonium salt → 1,3-bis(1,2-O-dimyristoyl-sn-glycero-3-phosphoryl)glycerol diammonium salt (63988-20-5)

Guidance literature:

With hydrogen; palladium; In tetrahydrofuran; for 3.5h;

Reference yield: 83.0%

1,3-bis(1,2-O-dimyristoyl-sn-glycero-3-phosphoryl)-2-O-(t-butyl dimethylsilyl) glycerol diammonium salt → 1,3-bis(1,2-O-dimyristoyl-sn-glycero-3-phosphoryl)glycerol diammonium salt (63988-20-5)

Guidance literature:

1,3-bis(1,2-O-dimyristoyl-sn-glycero-3-phosphoryl)-2-O-(t-butyl dimethylsilyl) glycerol diammonium salt; With hydrogenchloride; In methanol; chloroform; water; at 20 ℃; for 6h;

With ammonia; In methanol; chloroform; water; at 0 ℃;

upstream raw materials:

2-O-benzyl-1,3-bis[(1,2-di-O-myristoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Refernces

• 1、 -. "CARDIOLIPIN COMPOSITIONS THEIR METHODS OF PREPARATION AND USE". Page 22-23, 31, 34. . Retrieved 2010/02/04.