Ubiquinone Q6

Base Information

• Chemical Name: Ubiquinone Q6
• CAS No.: 7444-53-3
• Molecular Formula: C₃₉H₅₈O₄
• Molecular Weight: 590.887
• Mol file: 7444-53-3.mol

Synonyms:

Chemical Property of Ubiquinone Q6

Chemical Property:

• Storage Temp.: -20°C

Purity/Quality:

99% ^*data from raw suppliers

ANTI-COQ6 (N-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ubiquinone Q6

There total 7 articles about Ubiquinone Q6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-((2E,6E,10E,14E,18E)-3,7,11,15,19,23-Hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-2,3,4,5-tetramethoxy-6-methyl-benzene (118579-97-8) → All-Trans Coenzyme Q6 (1065-31-2,7444-53-3)

Guidance literature:

With ammonium cerium(IV) nitrate; In dichloromethane; water; acetonitrile;

DOI:10.1021/ja992164p

Reference yield:

2,3-dimethoxy-5-methylbenzene-1,4-diol (3066-90-8) → All-Trans Coenzyme Q6 (1065-31-2,7444-53-3)

Guidance literature:

Multi-step reaction with 4 steps

2: HCl

3: 88 percent / Ni(PPh₃)4 / tetrahydrofuran / 20 °C

4: 60 percent / Ce(NH₄)2(NO₃)6 / CH₂Cl₂; H₂O; acetonitrile

With hydrogenchloride; ammonium cerium(IV) nitrate; tetrakis(triphenylphosphine)nickel⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1: Methylation / 2: chloromethylation / 3: Alkylation / 4: Oxidation;

DOI:10.1021/ja992164p

Reference yield:

2,3-Dimethoxy-5-methyl-1,4-benzoquinone (605-94-7) → All-Trans Coenzyme Q6 (1065-31-2,7444-53-3)

Guidance literature:

With methanol; Lindlar's catalyst; Hydrogenation_.Erwaermen des Reaktionsprodukts mit (+-)-3,7,11,15,19,23-Hexamethyl-tetracosa-1,6t,10t,14t,18t,22-hexaen-3-ol und ZnCl₂ in Aether und wenig Essigsaeure und Behandeln des Reaktionsprodukts mit Ag₂O in Aether;

DOI:10.1002/hlca.19580410746

upstream raw materials:

2,3-Dimethoxy-5-methyl-1,4-benzoquinone

((2E,6E,10E,14E,18E)-3,7,11,15,19,23-Hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-trimethyl-stannane

1-((2E,6E,10E,14E,18E)-3,7,11,15,19,23-Hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-2,3,4,5-tetramethoxy-6-methyl-benzene

2,3-dimethoxy-5-methylbenzene-1,4-diol

Refernces

• 1、 Naruta. "Regio- and stereoselective synthesis of coenzymes Q(n) (n=2-10), vitamin K, and related polyprenylquinones". . p. 4097 - 4104. Retrieved 2007/10/02.