Ethyl 2-(2-oxoquinoxalin-1-yl)acetate

Base Information

• Chemical Name: Ethyl 2-(2-oxoquinoxalin-1-yl)acetate
• CAS No.: 154640-54-7
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Hs Code.: 2933998090
• European Community (EC) Number: 644-995-5
• ChEMBL ID: CHEMBL1545120
• Mol file: 154640-54-7.mol

Synonyms:154640-54-7;ethyl 2-(2-oxo-1,2-dihydroquinoxalin-1-yl)acetate;ethyl 2-(2-oxoquinoxalin-1-yl)acetate;ethyl 2-(3-oxo-3,4-dihydro-4-quinolinyl)acetate;MLS000541560;Ethyl 2-(2-oxoquinoxalin-1(2H)-yl)acetate;SMR000126418;CHEMBL1545120;BDBM55385;cid_3727805;HMS2325H07;MFCD05155084;AKOS005085428;2K-329S;Ethyl2-(2-oxoquinoxalin-1(2H)-yl)acetate;Ethyl 2-[2-oxo-1(2H)-quinoxalinyl]acetate;2-(2-oxo-1-quinoxalinyl)acetic acid ethyl ester;2-(2-ketoquinoxalin-1-yl)acetic acid ethyl ester;ETHYL (2-OXO-1(2H)-QUINOXALINYL)ACETATE;ethyl 2-(2-oxidanylidenequinoxalin-1-yl)ethanoate;SR-01000309058;SR-01000309058-1

Chemical Property of Ethyl 2-(2-oxoquinoxalin-1-yl)acetate

Chemical Property:

• Boiling Point: 384.3±44.0 °C(Predicted)
• PKA: -0.61±0.70(Predicted)
• Density: 1.25±0.1 g/cm3(Predicted)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 232.08479225
• Heavy Atom Count: 17
• Complexity: 341

Purity/Quality:

ETHYL 2-(3-OXO-3,4-DIHYDRO-4-QUINOLINYL)ACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)CN1C2=CC=CC=C2N=CC1=O

Technology Process of Ethyl 2-(2-oxoquinoxalin-1-yl)acetate

There total 10 articles about Ethyl 2-(2-oxoquinoxalin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl (2-oxo-3,4-dihydroquinoxalin-1(2H)-yl)acetate (1235982-73-6) → ethyl <2(1H)-quinoxalinon-1-yl>acetate (154640-54-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 60 ℃; for 0.5h;

DOI:10.1142/S1088424610001982

Reference yield: 66.0%

quinoxalin-2(1)-one (1196-57-2) → ethyl <2(1H)-quinoxalinon-1-yl>acetate (154640-54-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/d0ob01423k

Reference yield:

quinoxalin-2(1)-one (1196-57-2) → ethyl <2(1H)-quinoxalinon-1-yl>acetate (154640-54-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol4028946

upstream raw materials:

ethyl (2-oxo-3,4-dihydroquinoxalin-1(2H)-yl)acetate

quinoxalin-2⁽¹⁾-one

1,2-diamino-benzene

ethyl bromoacetate